… metabolism to mitochondrial aconitase (ACO2). Moreover, we find that inflammatory macrophages
reroute pyruvate away from pyruvate dehydrogenase (… metabolic rewiring, in vitro and …

… The native metabolism is shown in grey. (b) Metabolic rewiring of the pyruvate
dehydrogenase … In addition, a synthetic pyruvate dehydrogenase bypass [an acetate-acetyl-CoA/malonyl-…

… of metabolic rewiring during EMT that diverts glucose to the TCA cycle. Such rewiring was
at least partially mediated by the reduced expression of pyruvate dehydrogenase kinase 4 (…

… Moreover, the production of HNO is dependent on the lipoate-rich PDH complex
facilitating irreversible modifications that are critical to NO-dependent metabolic rewiring. …

… Shine-Dalgarno sequence of pyruvate dehydrogenase, which re-calibrated the PDC expression
levels and restored the optimal growth. We also observed a rewiring in the TCA flux and …

… understanding the metabolic rewiring involving … Metabolic rewiring of cancer cells permits
them to escape from housekeeping metabolic duties and switch to the synthesis of metabolic …

… In addition, we describe how systems biology tools benefit metabolic rewiring for advancing
… pyruvate dehydrogenase bypass was used to enable growth in a strain lacking pyruvate …

… in Th17 cells also through induction of the pyruvate dehydrogenase kinase 1 (PDHK1) (Fig.
1… enzyme pyruvate dehydrogenase (PDH) that catalyzes the oxidative conversion of pyruvate …

… of pyruvate in the TCA cycle facilitated by activity of the pyruvate dehydrogenase complex
(PDH… activity is regulated by modification by either pyruvate dehydrogenase kinases (PDKs) or …

… During aerobic growth on glucose, pyruvate is oxidized by pyruvate dehydrogenase … to
50% loss of pyruvate via carbon dioxide (12). Another part of pyruvate is recruited to synthesize …