… lot of quinazoline compounds have shown EGFR inhibition. … -anilinoquinazoline scaffold as
kinase inhibitors and they have led … quinazolines derivatives as anticancer drugs since 2011. …

… This work provides a collection of general drug design rules for the development of novel
quinazoline derivatives as potential EGFR inhibitors based on new quinazoline derivatives …

… Forty-five 4-anilino quinazoline derivatives having anticancer activities by EGFR kinase
inhibition were considered in the present study and used for kNN-MFA analysis (Bridges et al., …

… Based on the bioactivities of quinazolinone, our laboratory is … novel EGFR inhibitors. Initially,
we designed a new series of 2-substituted quinazolinone derivatives for EGFR-TK inhibitors…

… 6-position of quinazoline can result in EGFR/ErbB2 irreversible inhibition. Introducing the …
6-position of quinazoline can result in EGFR/ErbB2 multiple kinase inhibition. The presence of …

… Novel 2-chloro-4-anilino-quinazolines designed as EGFR and VEGFR-2 dual inhibitors were
synthesized and evaluated for inhibitory effects. EGFR and VEGFR-2 are validated targets …

… Development of small molecule dual-target inhibitors … of quinazoline derivatives bearing
a benzene-sulfonamide moiety were designed and synthesized as dual EGFR/CAIX inhibitors. …

Design of more potent quinazoline derivatives as EGFRWT inhibitors for the treatment of … a
common structure of quinazoline and acrylamide. Many EGFR inhibitors/NSCLC therapeutic …

… In this study, we report three different series of quinazoline derivatives bearing cinnamamide
scaffold as EGFR T790M mutation inhibitors. Optimization of the 4-anilino quinazoline and …

… quinazoline derivatives as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
… EGFR inhibitors were highly effective in the treatment of lung-cancer patients with activated …