… While the involvement of PhoPQ in causing resistance to cationic peptide antibiotics has
been reported (15), we were surprised that PhoPQ also played a role in quinolone susceptibility …

… Colistin is an important cationic antimicrobial peptide (CAMP) in the fight against … Most
striking was the upregulation of Pseudomonas quinolone signal (PQS) biosynthesis genes, …

… To confirm the disrupted action on the OM via the chelation of divalent cations with quinolones,
we asked whether divalent cations could inhibit the increase in NPN fluorescence. We …

… These proteins provide a path through the outer membrane for small hydrophilic antibiotics,
such as quinolones. In bacteria generally, the cellular concentration of quinolone antibiotics …

… growing interest in cationic antimicrobial peptides (CAMPs) … by covalently affixing a
fluoroquinolone antibiotic, levofloxacin, … of small molecule antibiotics with favorable …

… Cationic peptides derived from polymyxin B have been used to permeabilize the outer
membrane, granting antibiotics … pneumoniae; the efficacy of the quinolone antibiotics ciprofloxacin …

… tract infections are resistant to fluoroquinolones. Peptide antibiotics are viable alternatives
… , we designed multifunctional proline-rich antibacterial peptides that maintained their DnaK-…

… The fluoroquinolone antibiotic ciprofloxacin targeting DNA gyrase was used as a control. …
This feature of PQ401 in comparison to cationic antimicrobial peptides significantly expands …

… that the presence of cations interferes with the interaction between the quinolone and the
self-promoted uptake pathway, resulting in a decrease in accumulation of the antibiotic. The self…

… Antimicrobial cationic peptides (AMPs) are major components of … , cationic peptides are
not affected by many antibiotic resistance mechanisms that now limit the use of other antibiotics (…