… would be currently missed using standard rabbit model sampling. As Table 2 … rabbit
vegetations. The result of this study indicates the in vitro model to be comparable to the rabbit model …

… In vivo models of IE are mostly based on rabbits, rats, and mice. These … When comparing
our model to another in vitro model for IE, (simulated endocardial vegetations, SEV), we receive …

… Recently, simulation of human pharmacokinetics in rabbits has improved the … of endocardial
vegetations have also been well established by the use of the rabbit endo- carditis model. …

… to simulate doses in humans of 6 mg/kg and 10 mg/kg, respectively. Endocardial vegetations,
… The number of CFU in endocardial vegetations of rabbits treated with the 18-mg/kg dose …

… of MRSA infective endocarditis (ie, cardiac vegetations, … model featuring ex vivo simulated
endocardial vegetations (SEVs). … model would mirror similar findings in the rabbit endocarditis …

… The rabbit model of catheter-induced IE used in the present … To simulate binding of S
aureus to vegetations, the … directly to platelets on damaged endocardium, this ASA effect might …

… endocardial vegetation and the weight of any vegetations present; level of infection in the
vegetations … with low bacterial inocula, simulating what probably happens when prosthetic …

… formation in a rabbit endovascular infection model. Using … rabbits resulted in rapid colonization
of the endocardium … of distinct vegetations, our findings are consistent with a model of …

… were chosen to be simulated in the rabbits: cloxacillin (2 g/4 h … All control rabbits had infected
aortic valve vegetations, with … capacity to sterilize endocardial vegetations compared with …

… control rabbits had infected aortic valve vegetations, with a median bacterial titer equal to 10
log 10 CFU/g of vegetation (… were separated into different treatment arms simulating human …