… Based on a prospective dose escalation trial, the current study demonstrates that dose, as
a continuous variable, is significantly associated with OS and locoregional disease control. …

… radiation-dose escalation trial designed to test a hypothesis that very high doses of radiation
… –small-cell lung cancer (NSCLC) by quantifying the dose–volume toxicity relationship of the …

… Radiation therapy was initially planned to be given by a dose escalation design using
increasing doses per fraction (75.25 Gy at 2.15 Gy per fraction, 80.5 Gy at 2.3 Gy per fraction, 79.5 …

… dose) with concurrent and consolidation chemotherapy with or without cetuximab. This study
asked whether or not RT dose escalation (… rate was lower in the high-dose RT arm, and the …

… to establish the maximum tolerated dose. The trial was initially designed to dose escalate by
increasing the … Because doses of 90.3 Gy on RTOG 9311 took over 9 weeks to deliver, this …

… time in a Phase I trial (Step 3) Step 3 of this study will involve dose escalation in a classic
Phase I … , for each volume bin, the maximum tolerated dose (MTD). This is defined as the largest …

… increase in the dose might translate … I dose escalation trial at the University of Michigan in
1992 with the primary objective of establishing the maximum-tolerated dose (MTD) of radiation …

… studies in radiation dose intensification are underway. Recently, the Radiation Therapy
Oncology Group opened a Phase I study … this trial will not be available for several years (11). The …

… radiotherapy include dose escalation with altered fractionation, individualised radiation dose
escalation based on normal tissue dose … , stereotactic ablative radiotherapy boost, and the …

… to treatment of unresectable stage III lung cancer, and we outline the early and the more
recent dose escalation studies. While dose escalation appears to provide a modest benefit in …