Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways

S Dong, J Kong, F Kong, J Kong, J Gao, S Ke… - Journal of Translational …, 2013 - Springer
Akt and p-ERK1/2, and PI3K inhibitor, LY294002, and ERK inhibitor, PD98059, significantly
inhibited the expression of p-Akt … EMT of HCC cells through Akt and ERK signaling pathways. …

Insufficient radiofrequency ablation promotes the growth of non-small cell lung cancer cells through PI3K/Akt/HIF-1α signals

J Wan, W Wu, Y Chen, N Kang… - Acta Biochim Biophys …, 2016 - academic.oup.com
… PI3K/Akt participates in … /Akt inhibitor LY294002 and ERK inhibitor PD98059 were used
according to previous studies [20]. As shown in Fig. 4A, PI3K/Akt inhibitor LY294002, but not ERK

Mechanism of action of radiofrequency ablation

F Vahedifard, M Malinowski, K Chakravarthy - … of radiofrequency ablation …, 2021 - Springer
RF ablation in the literature. Accordingly, this chapter aims to provide a comprehensive review
of various aspects of RF ablation… activity occurs after nerve damage, and inhibition of ERK

Insufficient radiofrequency ablation promotes human hepatoma SMMC7721 cell proliferation by stimulating vascular endothelial growth factor overexpression

Z Liu, H Dai, G Jia, Y Li, X Liu… - Oncology letters, 2015 - spandidos-publications.com
… of insufficient radiofrequency ablation (RFA) … ERK activation triggered by the 47C heat
treatment may be CaMKII-dependent. ERK phosphorylation was inhibited by PD98059 (an ERK

An overview of hepatocellular carcinoma after insufficient radiofrequency ablation

Y Guo, Y Ren, X Dong, X Kan… - Journal of Hepatocellular …, 2022 - Taylor & Francis
… , HuH7, and HEP3B cell lines and found that ERK was significantly phosphorylated. EMT was
… Periostin were activated as upstream proteins of ERK after heat treatment, causing tumor …

[HTML][HTML] Insufficient radiofrequency ablation treated hepatocellular carcinoma cells promote metastasis by up-regulation ITGB3

N Zhang, D Ma, L Wang, X Zhu, Q Pan, Y Zhao… - Journal of …, 2017 - ncbi.nlm.nih.gov
AKT in vitro were detected by western blot. D The effects of inhibiting the phosphorylation of
AKT … β6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the …

Sorafenib suppresses the epithelial-mesenchymal transition of hepatocellular carcinoma cells after insufficient radiofrequency ablation

S Dong, J Kong, F Kong, J Kong, J Gao, L Ji, B Pan… - BMC cancer, 2015 - Springer
Radiofrequency ablation (RFA) is emerging as an effective local treatment for curative intent
… cells and the EMT of HCC cells through Akt and ERK signaling pathways [11]. However, …

HMGB1 released from dead tumor cells after insufficient radiofrequency ablation promotes progression of HCC residual tumor via ERK1/2 pathway

Y Zhou, X Liu, W Zhang, Y Xu, Q Zhang… - International Journal …, 2023 - Taylor & Francis
… prognosis of HCC after radiofrequency ablation. … /ERK signaling pathway is a classical
pathway correlated with tumor proliferation and invasion. Based on HCC studies, the MEK/ERK

[HTML][HTML] Insufficient radiofrequency ablation-induced autophagy contributes to the rapid progression of residual hepatocellular carcinoma through the HIF-1α/BNIP3 …

WL Xu, SH Wang, WB Sun, J Gao, XM Ding, J Kong… - BMB …, 2019 - ncbi.nlm.nih.gov
… In addition, we also found that epithelial-mesenchymal transition (EMT) involving the AKT/ERK
signaling pathways play a vital role in the invasiveness and metastasis of the residual …

Epidermal growth factor receptor transactivation is involved in the induction of human hepatoma SMMC7721 cell proliferation by insufficient radiofrequency ablation

H Dai, G Jia, H Wang, J Yang, H Jiang… - Oncology …, 2017 - spandidos-publications.com
… For example, a recent study revealed that Akt and ERK signaling activation … /ERK-VEGF
signaling cascades and EGFR transactivation was investigated. The MAPK kinase (MEK)/ERK