Clinical applications for radiotracer imaging of lower extremity peripheral arterial disease and critical limb ischemia

TH Chou, MR Stacy - Molecular imaging and biology, 2020 - Springer
… continue to evolve, opportunities for molecular imaging of PAD … radiotracer-based techniques
that have been utilized in the clinical environment for evaluating lower extremity ischemia

Radiotracer imaging allows for noninvasive detection and quantification of abnormalities in angiosome foot perfusion in diabetic patients with critical limb ischemia …

JL Alvelo, X Papademetris… - … Imaging, 2018 - Am Heart Assoc
… In the present study, we demonstrate that radiotracer-based imaging with single photon …
control subjects and diabetic patients with critical limb ischemia and is also capable of detecting …

Prognostic value of radiotracer-based perfusion imaging in critical limb ischemia patients undergoing lower extremity revascularization

TH Chou, JL Alvelo, S Janse, X Papademetris… - … Imaging, 2021 - jacc.org
Radiotracer imaging can assess microvascular foot perfusion and identify regional
perfusion abnormalities in patients with critical limb ischemia CLI and DM, but the relationship …

Radiotracer imaging of peripheral vascular disease

MR Stacy, W Zhou, AJ Sinusas - Journal of Nuclear Medicine, 2013 - Soc Nuclear Med
… With the emergence of 3-dimensional SPECT imaging systems, it was … -extremity ischemia
under both rest and stress conditions with 201 Tl (24). One of the first lower-extremity imaging

SPECT/CT imaging: a noninvasive approach for evaluating serial changes in angiosome foot perfusion in critical limb ischemia

TH Chou, SA Atway, AJ Bobbey, TP Sarac… - Advances in wound …, 2020 - liebertpub.com
… of an ongoing NIH supported clinical trial focused on radiotracer-based imaging for
evaluation of perfusion responses to revascularization in patients with critical limb ischemia. …

PET/SPECT imaging of hindlimb ischemia: focusing on angiogenesis and blood flow

H Orbay, H Hong, Y Zhang, W Cai - Angiogenesis, 2013 - Springer
… murine hindlimb ischemia model, and a number of radiotracers have been … imaging the
biological processes (eg, angiogenesis) during extremity ischemia using the molecular imaging

[HTML][HTML] SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease

G Hendrikx, S Vöö, M Bauwens, MJ Post… - … and Molecular Imaging, 2016 - Springer
… Alluding to the inferior amount of work being published on radiotracer imaging of … of pro-angiogenic
growth factors, and in hind limb ischemia. Enhanced angiogenesis post-MI has been …

[HTML][HTML] Multimodal and multiscale analysis reveals distinct vascular, metabolic and inflammatory components of the tissue response to limb ischemia

T Kapanadze, JP Bankstahl, A Wittneben… - Theranostics, 2019 - ncbi.nlm.nih.gov
ischemic tissue response and to elucidate the cellular substrate of noninvasive molecular
imaging techniques in a mouse model of hind limb ischemia… to HLI with the radiotracer [ 99m Tc…

[HTML][HTML] Applications of SPECT and PET Imaging for the Physiological Evaluation of Lower Extremity Peripheral Artery Disease

ET Rimmerman, MR Stacy - International Journal of Molecular Sciences, 2024 - mdpi.com
… to hindlimb ischemia in a rodent model. This initial research work revealed that a peak
angiogenic response to limb ischemia was detectable by microPET imaging approximately 1 …

Noninvasive Imaging of Angiogenesis With a 99mTc-Labeled Peptide Targeted at αvβ3 Integrin After Murine Hindlimb Ischemia

J Hua, LW Dobrucki, MM Sadeghi, J Zhang… - Circulation, 2005 - Am Heart Assoc
… of angiogenesis associated with peripheral limb ischemia. NC100692 is a … ischemia–induced
angiogenesis. This noninvasive approach for targeted α v β 3 integrin radiotracer imaging