… GTPase Rag and lysosomal tethering of Rag-Ragulator were required to recruit and activate
the kinase RIPK1 and protease caspase-8 … By contrast, Rag-Ragulator was not required for …

… Ragulator-Rag complex as being necessary for GSDMD pore formation and pyroptosis in
macrophages. Mechanistic analysis revealed that Ragulator-Rag is … caspase-11 (or caspase-4 …

… When cFLIP L is present in low concentrations it acts as a positive regulator of caspase-8 …
Reconstitution of RAG-1 deficient blastocysts with FADD deficient embryonic stem cells, …

… caspase-8–deficient macrophages are prone to a caspase-independent death in response
to death receptor ligation; yet, caspase-8–… a role for caspase-8 as a regulator of both the TLR …

… An important regulator of caspase-8 is the catalytically inactive caspase-8 homolog, cFLIP,
which heterodimerizes with caspase-8 to control its activity and substrate profile. The short …

… À/À Mlkl À/À mice did not alter their phenotype, our genetic models formally show that
caspase8 has a FADD-independent role in regulating inflammation in a setting where it is unable …

… In addition, we show that the deletion of caspase 8 specifically in murine GC-B cells results
in larger GCs and a delay in affinity maturation, demonstrating the importance of apoptosis in …

… Ragulator-Rag complex, which is known for its metabolic control of mTOR. Mechanistic studies
revealed that Ragulator-Rag … by the actions of murine caspase-11 (or caspase-4 and −5 …

… shortening in mice lacking caspase 8 in IECs but instead … Consistent with direct activation
of the TLR3–TRIF–caspase 8 … of the TLR3–TRIF–caspase 8 signaling pathway in IECs has a …

… The OT-I Rag −/− transgenic mice were bred by our laboratory. All mice were maintained in
the animal … -independent death by Bay11, we tested the effects of a caspase 8 inhibitor and …