… This phase III trial enrolled patients older than age 18 years with a Karnofsky performance
… Patients were randomly assigned to standard temozolomide (arm 1) or DD temozolomide (…

… , randomised, open-label, phase III study of extended schedule and escalated dose of
temozolomide versus standard dose … if the extended schedule of temozolomide is a more effective …

… a multicenter, phase II study to assess the efficacy and safety of continuous dose-intense …
Randomized, comparative trials are needed to determine the optimal regimen for patients with …

… IV at a higher dose than that of temozolomide, the mean … temozolomide-treated group.
Similar levels of nausea and vomiting were seen in phase II trials of this drug, but, as in this study, …

… 200 mg/m 2 orally daily for 5 days given every 28 days, and the dose and frequency were …
randomised studies against other management policies. On the basis of the available data, …

… A prior phase I study established a chronic daily temozolomide dose that significantly
increased the total dose … A recent randomized clinical trial failed to show any benefit (Medical …

… a phase II trial using a similar regimen of temozolomide 50 mg/… historical controls and typical
clinical trials in glioblastoma, 4,… Dedicated randomized trials are thus needed to define the …

… Temozolomide (TMZ), an oral alkylating agent, has shown promising activity in the treatment
of malignant gliomas. We conducted a multicenter randomized phase II study comparing …

… relative to standard dosing. Therefore, we designed a randomized phase II trial to evaluate
… appropriate, to recommend one arm for a phase III trial. To facilitate use of the EORTC/NCIC …

… The planned randomised phase II trial was discontinued right at its onset due to industry …
dose, and the dose level below would be considered the recommended dosage for phase II. A …