Use of erlotinib or gefitinib as initial therapy in advanced NSCLC

GR Oxnard, VA Miller - Oncology, 2010 - search.proquest.com
… (EGFR), such as erlotinib (Tarceva) and gefitinib (Iressa), have shown … randomized controlled
trial showing a survival benefit compared with placebo, erlotinib gained US Food and Drug

Gefitinib provides similar effectiveness and improved safety than erlotinib for advanced non-small cell lung cancer: A meta-analysis

W Zhang, Y Wei, D Yu, J Xu, J Peng - Medicine, 2018 - journals.lww.com
Gefitinib was proven to be the better choice for advanced NSCLC, with equal antitumor …
AEs compared with erlotinib. Further large-scale, well-designed randomized controlled trials are …

[HTML][HTML] Use of the epidermal growth factor receptor inhibitors gefitinib and erlotinib in the treatment of non-small cell lung cancer: a systematic review

R Feld, SS Sridhar, FA Shepherd, JA Mackay… - Journal of Thoracic …, 2006 - Elsevier
… abstracts of randomized controlled trials (phase II or phase III) comparing gefitinib or erlotinib,
alone … , or comparing different doses or schedules of gefitinib or erlotinib. Data on symptom …

Randomized phase III study comparing gefitinib with erlotinib in patients with previously treated advanced lung adenocarcinoma: WJOG 5108L

Y Urata, N Katakami, S Morita, R Kaji… - Journal of Clinical …, 2016 - ascopubs.org
… This study aimed to investigate the noninferiority of gefitinib compared with erlotinib. The
primary … On the basis of these factors, we established our trial as a noninferiority clinical trial. …

[HTML][HTML] The efficacy and toxicity of gefitinib in treating non-small cell lung cancer: a meta-analysis of 19 randomized clinical trials

H Wo, J He, Y Zhao, H Yu, F Chen, H Yi - Journal of Cancer, 2018 - ncbi.nlm.nih.gov
… database, the Cochrane Central Register of Controlled Trials (CENTRAL), the China …
following terms: gefitinib, non-small cell lung cancer, NSCLC, and randomized controlled trial. The …

… of chemotherapy and gefitinib as first‐line treatment for patients with advanced lung adenocarcinoma and sensitive EGFR mutations: a randomized controlled trial

B Han, B Jin, T Chu, Y Niu, Y Dong, J Xu… - … journal of cancer, 2017 - Wiley Online Library
study was a three-arm randomized open-label phase II study … and gefitinib to either pemetrexed
plus carboplatin or gefitinib alone … -2 study, intercalating chemotherapy with erlotinib.23 …

Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy

ST Kim, JE Uhm, J Lee, J Sun, I Sohn, SW Kim… - Lung Cancer, 2012 - Elsevier
… Several meta-analysis of randomized clinical trials have demonstrated that platinum-based
combination chemotherapy is able to induce a modest but significant survival advantage …

Comparison of effectiveness and adverse effects of gefitinib, erlotinib and icotinib among patients with non‑small cell lung cancer: A network meta‑analysis

Y Liu, Y Zhang, G Feng, Q Niu… - Experimental and …, 2017 - spandidos-publications.com
clinical trials comparing the success rate of gefitinib, erlotinib and icotinib have been reported.
In the current study, … The quality of randomized controlled trials from the Cochrane network …

Erlotinib in combination with bevacizumab has potential benefit in non-small cell lung cancer: a systematic review and meta-analysis of randomized clinical trials

B Zhao, W Zhang, D Yu, J Xu, Y Wei - Lung Cancer, 2018 - Elsevier
Clinical studies have gradually demonstrated that activating … Gefitinib and erlotinib, both
regarded as first-generation EGFR… and dacomitinib improved PFS compared to gefitinib [58,59]; …

… , metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial

VA Miller, V Hirsh, J Cadranel, YM Chen, K Park… - The lancet …, 2012 - thelancet.com
… The randomisation sequence was generated by an independent team from the trial sponsor
with a validated computer system (clinical trial supply system). This team was not involved in …