… gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial

K Park, EH Tan, K O'Byrne, L Zhang, M Boyer… - The Lancet …, 2016 - thelancet.com
… A search of ClinicalTrials.gov showed that several randomised trials comparing EGFR tyrosine
kinase inhibitors are ongoing, including: a phase 2 trial comparing erlotinib and gefitinib (…

Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non–small-cell lung cancer

LV Sequist, J Von Pawel, EG Garmey… - Journal of Clinical …, 2011 - ascopubs.org
… To our knowledge, this is the first large randomized clinical trial of an MET-targeted inhibitor
to be reported in NSCLC. We evaluated erlotinib plus the specific MET inhibitor tivantinib …

Combined Survival Analysis of Prospective Clinical Trials of Gefitinib for Non–Small Cell Lung Cancer with EGFR Mutations

S Morita, I Okamoto, K Kobayashi, K Yamazaki… - … Cancer Research, 2009 - AACR
… Several prospective clinical trials of gefitinib or erlotinib for treatment of non–small cell lung
… review and meta-analysis of individual patient data from 16 randomized controlled trials. …

Efficacy of erlotinib in patients with advanced non-small cell lung cancer: a pooled analysis of randomized trials

H Gao, X Ding, D Wei, P Cheng, X Su, H Liu… - Anti-Cancer …, 2011 - journals.lww.com
… The aim of this study was to evaluate the efficacy of erlotinib … analysis of randomized controlled
trials that compared erlotinib-… EGFR pathway, such as gefitinib and erlotinib. To date, the …

Erlotinib for advanced non–small-cell lung cancer in the elderly: an analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR. 21

P Wheatley-Price, K Ding, L Seymour… - Journal of Clinical …, 2008 - ascopubs.org
… III trial that randomly assigned 731 patients to erlotinib 150 mg … Gefitinib has now been
compared with docetaxel in the … randomized phase II and two randomized phase III trials. These …

Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non–small-cell lung cancer

R Pérez-Soler - Clinical lung cancer, 2004 - Elsevier
… use of erlotinib or gefitinib in early-… study confirms the antitumor activity of erlotinib as first-line
therapy in patients with NSCLC who may be poor candidates for chemotherapy. This study

Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects

G Bronte, C Rolfo, E Giovannetti, G Cicero… - Critical reviews in …, 2014 - Elsevier
study showed that sensitivity to erlotinib and gefitinib differed among several EGFR mutations
at exon 19 [35]. Moreover, gefitinib and erlotinib … following clinical trials compared gefitinib

[HTML][HTML] Efficacy and safety of afatinib for EGFR-mutant non-small cell lung cancer, compared with gefitinib or erlotinib

Y Kim, SH Lee, JS Ahn, MJ Ahn… - Cancer Research and …, 2019 - synapse.koreamed.org
… Our purpose of this study is to investigate how afatinib is used in real-world practice, and
whether it leads to different clinical outcomes compared with gefitinib or erlotinib. …

… Tyrosine Kinase Inhibitor Discontinuation in Patients with EGFR-Mutant Lung Cancer and Acquired Resistance to Erlotinib or Gefitinib: Implications for Clinical Trial …

JE Chaft, GR Oxnard, CS Sima, MG Kris, VA Miller… - … cancer research, 2011 - AACR
… define the course of patients following TKI discontinuation, we systematically evaluated
patients enrolled on clinical trials of agents to treat acquired resistance to erlotinib or gefitinib. …

[HTML][HTML] … of erlotinib 100 mg/d vs. gefitinib 250 mg/d in EGFR-mutated advanced non-small cell lung cancer (E100VG250): an open-label, randomized, phase 2 study

S Zhao, Z Zhang, W Fang, Y Zhang, Z Zhang… - Frontiers in …, 2020 - frontiersin.org
randomized controlled trial to directly compare lower dose erlotinib with standard dose gefitinib
… Therefore, in Stage IV EGFR mutated NSCLC, this study showed that erlotinib 100 mg/d …