The effectiveness of early treatment with “second-line” antirheumatic drugs: a randomized, controlled trial

A van der Heide, JWG Jacobs, JWJ Bijlsma… - Annals of internal …, 1996 - acpjournals.org
trials have shown this strategy to be … the treatment pyramid for patients with recent-onset
rheumatoid arthritis. In this report, we describe the first-year results of a randomized clinical trial

Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C …

CS Fuchs, J Marshall, E Mitchell… - Journal of Clinical …, 2007 - ascopubs.org
… This study in the first-line treatment of metastatic colorectal … Earlier randomized trials
comparing infusional to bolus FU/… In a previous Intergroup study of first-line therapy for metastatic …

[HTML][HTML] … of bevacizumab added to standard chemotherapy in metastatic colorectal cancer: final results for first-line treatment from the ITACa randomized clinical trial

A Passardi, O Nanni, D Tassinari, D Turci, L Cavanna… - Annals of …, 2015 - Elsevier
… a first-line phase III randomized clinical trial on metastatic colorectal cancer (mCRC) aimed
at evaluating the effectiveness of adding bevacizumab (B) to standard first-line chemotherapy …

First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial

GJ Morgan, FE Davies, WM Gregory, K Cocks, SE Bell… - The Lancet, 2010 - thelancet.com
… has shown potential anticancer effects in preclinical and clinical studies. We aimed to establish
whether bisphosphonates can affect clinical outcomes in patients with multiple myeloma. …

… combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials

G Folprecht, MT Seymour, L Saltz… - Journal of Clinical …, 2008 - ascopubs.org
… (FU)/folinic acid (FA) in the first-line therapy of metastatic colorectal cancer (CRC) has been
associated in randomized clinical trials with an increase in the median overall survival of …

Surgical or medical decompression as a firstline treatment of optic neuropathy in Graves' ophthalmopathy? A randomized controlled trial

I Wakelkamp, L Baldeschi, P Saeed… - Clinical …, 2005 - Wiley Online Library
… We performed a randomized controlled trial comparing intravenous pulse therapy with
methylprednisolone and decompressive surgery. The eligible patients were all consecutive …

… of chemotherapy and gefitinib as firstline treatment for patients with advanced lung adenocarcinoma and sensitive EGFR mutations: a randomized controlled trial

B Han, B Jin, T Chu, Y Niu, Y Dong, J Xu… - … journal of cancer, 2017 - Wiley Online Library
… Our study was a three-arm randomized open-label phase II study comparing … as first-line
therapy for lung adenocarcinoma patients harboring sensitive EGFR mutations. The study was …

Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials

M Pahor, BM Psaty, MH Alderman, WB Applegate… - The Lancet, 2000 - thelancet.com
… as first-line therapy, but also that the surrogate index, blood-pressure lowering, is not a
consistent and valid marker of the therapeutic benefit of all antihypertensive agents. The value of …

[HTML][HTML] … capecitabine as maintenance therapy after induction of XELOX (or FOLFOX) in first-line treatment of metastatic colorectal cancer: randomized clinical trial of …

HY Luo, YH Li, W Wang, ZQ Wang, X Yuan, D Ma… - Annals of …, 2016 - Elsevier
clinical trial that evaluated the efficacy and safety of single agent of capecitabine was the
maintenance therapy after first-line … and comparable with that of other similar studies [10., 11., 12…

Surrogate end points for median overall survival in metastatic colorectal cancer: literature-based analysis from 39 randomized controlled trials of first-line …

PA Tang, SM Bentzen, EX Chen, LL Siu - Journal of Clinical Oncology, 2007 - ascopubs.org
… Thirty-nine randomized controlled trials were identified containing a total of 87 treatment
of randomized controlled trials of first-line chemotherapy for MCRC to date, and included recent …