… We included a total of 276 participants enrolled in 6 randomized controlled trials, with a …
and clinical characteristics of the study participants are summarized in Table 1. All 6 trials …

… an ejection fraction ≤40%. We did not include trials with HF with preserved ejection fraction
(HFpEF) as the sex distribution in this condition is different from HFrEF and trial publications …

… Randomized clinical trials using gene transfer to improve function of the failing heart are the
… Four randomized clinical trials of gene transfer in heart failure with reduced ejection fraction (…

… study Although recently introduced therapies have each individually been tested in randomised
controlled trials, our study … from three contemporary randomised clinical trials of patients …

… Here, we compared individual patient data of five HFrEF randomized clinical trials and two
HF registries by direct data access and collaboration between academic researchers and …

… prospectively evaluated in randomized controlled trials (RCTs). The current study is one of
the first RCTs to assess an AI-powered clinical decision support tool in routine practice. The …

… The improvement in left-ventricular ejection fraction (LVEF) in response to β blockers is
heterogeneous in … We designed a randomised placebo-controlled trial to address this issue. …

… heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. …
failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial. …

… —age, sex, ejection fraction, NT-proBNP level, and … ejection fraction values, we imputed
the population median. We also performed the primary end point analysis with site as a random …

… The aim of the present randomized double-blind, placebo-controlled trial was to investigate
the effects of sildenafil on invasive haemodynamic measurements and exercise capacity in …