… Based on the similar efficacy observed between pemetrexed and docetaxel in separate
trials and the expected lower toxicity rates with pemetrexed, a multinational phase III study …

… AURELIA is the first randomized phase III trial to our knowledge combining bevacizumab …
To our knowledge, AURELIA is the first randomized phase III trial to demonstrate a PFS benefit …

… Chemotherapy Trial of S-1 for Gastric Cancer (ACTS-GC) is a randomized phase III trial to …
surgery alone in patients with stage II or III gastric cancer who underwent D2 gastrectomy. S-1 (…

… The purpose of this review is to provide an evidenced-based analysis of randomized phase
II and phase III trials that have evaluated the role of taxanes for the management of breast …

… to consider foregoing randomized phase III trials for certain drugs before drug approval. We
explore the consequences (both good and bad) of foregoing randomized phase III trials and …

… We carried out a prospective, two-arm, randomized, multi-institutional phase III trial to test
whether enhancing the drug's concentration in urine would improve its efficacy. Methods: …

Background In designing phase III randomized clinical trials (RCTs), the expected magnitude
of the benefit of the experimental therapy (δ) determines the number of patients required …

… The FLAME-trial (F ocal L esion A blative M icroboost in prostatE cancer) is a single blind
randomized controlled phase III trial. We aim to include 566 patients (283 per treatment arm) …

In 1986, we initiated a multicenter, randomized trial to compare induction chemotherapy with
cisplatin and 5-fluorouracil followed by locoregional treatment (surgery and radiotherapy or …

… Our phase III trial, … The phase III trial of sunitinib versus sorafenib was terminated early
owing to safety and lack of efficacy (median OS, 7.9 v 10.2 months; HR, 1.30). The phase III trial of …