[HTML][HTML] Selective regulation of MAPK signaling mediates RANKL-dependent osteoclast differentiation

K Lee, YH Chung, H Ahn, H Kim, J Rho… - International Journal of …, 2016 - ncbi.nlm.nih.gov
… on p38 activation via the RANKL-RANK-TRAF6 axis. Our … of MAPK signaling induced by
M-CSF and by RANKL mediates the proliferation versus differentiation decision in osteoclast

[PDF][PDF] Signaling pathways in osteoclast differentiation

JH Kim, N Kim - Chonnam medical journal, 2016 - synapse.koreamed.org
… naling, RANKL-RANK signaling, and costimulatory signaling for … The importance of
TRAF6-dependent MAPK activation was … MAPK-mediated signals are required for inducing …

The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation

SE Lee, KM Woo, SY Kim, HM Kim, K Kwack, ZH Lee… - Bone, 2002 - Elsevier
RANKL dependent mouse bone marrow and bone resident precursor cell cultures. Another
MAPK pathway … cocultures, osteoclast differentiation was evoked by RANKL expressed on …

[HTML][HTML] Current understanding of RANK signaling in osteoclast differentiation and maturation

JH Park, NK Lee, SY Lee - Molecules and cells, 2017 - Elsevier
… ) reported that the reactive oxygen species produced by the RANK-TRAF6-Rac1-NADPH
oxidase 1-dependent pathway are also required for MAPK activation and osteoclastogenesis. …

RANK signaling pathways and key molecules inducing osteoclast differentiation

NK Lee - Biomedical Science Letters, 2017 - koreascience.kr
… mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors. Science
… Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to …

Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway

H Huang, EJ Chang, J Ryu, ZH Lee, Y Lee… - … and biophysical research …, 2006 - Elsevier
… p38 MAPK signaling pathway is also involved in the Fos family member expression during
osteoclast differentiation, … We further demonstrated that p38-dependent NFATc1 expression is …

A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

NK Lee, YG Choi, JY Baik, SY Han, D Jeong, YS Bae… - Blood, 2005 - ashpublications.org
… with RANKL responses, including MAP kinase activation and osteoclast differentiation, we
… and monocytes through RANKL-TRAF6-Rac1-NADPH oxidase–dependent pathways may …

Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand (RANKL)

M Matsumoto, T Sudo, T Saito, H Osada… - Journal of Biological …, 2000 - ASBMB
… In a dose-dependent manner, SB203580 but not PD98059, … of MAP kinase families in
the RANKL-RANK signaling pathway … the p38 MAP kinase pathway plays a role in RANKL-induced …

Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-κB transactivation by RANKL

H Huang, J Ryu, J Ha, EJ Chang, HJ Kim… - … Death & Differentiation, 2006 - nature.com
… In this study, we found that p38 MAPK upstream components … This differentiation stage-dependent
activation of p38 by RANKL … , we investigated whether this MAPK signalling pathway is …

The molecular understanding of osteoclast differentiation

M Asagiri, H Takayanagi - Bone, 2007 - Elsevier
… The differentiation of osteoclasts is dependent on a tumor … events induced by RANKL during
osteoclast differentiation. … that MAPKs play an important role in osteoclastogenesis, but in …