… The bone-cartilage interface is an important … cartilage and subchondral bone are not well
understood. This review focuses on the regulatory processes at the cartilage-subchondral bone …

… of RANKL and OPG in bone is a major determinant of bone … role of the RANKL/RANK/OPG
system in bone modeling and … bone matrix on the surfaces of these islands of cartilage to …

… mutant mice 19 exhibit significant changes in the columnar alignment of chondrocytes at
the growth plate, it is possible that RANKL/RANK play a direct part in cartilage growth and …

… Cartilage damage was still observed in both arthritic rankl knockout mice and … cartilage
damage in the rankl -/- mice was noted. Thus, it appears that RANKL is not required for cartilage …

… bone morphology have been considered to be important factors in OA. The variation in cartilage
RANKL … study is consistent with cartilage regulating bone metabolism and contributing to …

… bone next to marrow and conserving normally used bone. … that monitors bone metabolism
(longitudinal growth, bone … /RANKL/RANK proteinic system regulates bone metabolism by …

… However, cartilage damage was still observed in both arthritic Rankl −/− and … cartilage
damage in the Rankl −/− mice was noted. Thus, it appears that RANKL is not essential for cartilage …

… The promising preclinical results led to the initiation of clinical trials to evaluate inhibition of
the RANK–RANKL system in patients with osteoporosis, RA and other conditions associated …

… A third point of discussion is the role of RANKL in cartilage biology. Although RANKL and
RANK … It is unclear whether inhibition of RANKL can preserve cartilage through direct effects on …

… members have important functions outside bone. Although our … of the RANKL/RANK/OPG
system in bone and other tissues. … cartilage, bone is continuously renewed by the process of …