… Boosted by the successes of FDA-approved Adcetris ® and Kadcyla ® , this drug class has
been rapidly growing along with about 60 ADCs currently in clinical trials. In this article, we …

… the rapid conjugation and generation of antibody-drug combinations to facilitate early antibody
… of promising antibody-drug pairs for future ADC development. This methodology relies on …

… To demonstrate that the Fc region per se was not responsible for the rapid drug loss
observed with the Fc-S396C conjugate, we selected two other accessible Fc region …

… demonstration of a rapid “middle-up… conjugated maleimidocaproyl-monomethyl auristatin
F (mcMMAF) and valine-citrulline-monomethyl auristatin E (vcMMAE) antibody–drug conjugates…

… conjugation method to reduce the number of drug equivalents needed for sufficient conjugation…
Since Adcetris is modified with an average of four vedotin molecules per antibody, 28 we …

… Cysteine-conjugated antibody-drug conjugates (ADCs) are manufactured using controlled
partial reduction and conjugation chemistry with drug payloads that typically occur in intervals …

… The highly solvent-accessible site rapidly lost conjugated thiol-reactive linkers in plasma
owing to maleimide exchange with reactive thiol groups in albumin, free cysteine or glutathione …

… the rapid production of stable therapeutic protein conjugates. … and rapid conjugation of
diverse therapeutic antibodies with … coupled to its rapid and quantitative conjugation to generate …

… It was hypothesised that pAMF would enable more rapid SPAAC conjugation compared to
pAzF, due to the azido group being further from the electron withdrawing phenyl ring, hence …

… Antibody–drug conjugates (ADC) are a rapidly growing class of targeted cancer treatments,
… We found that rapid release of the SN-38 payload from the hydrolysable linker inside cells …