… describe the structural features of rare EGFR mutations and elaborate on the preclinical
and clinical evidence for EGFRi response for patients that harbour such rare EGFR mutations. …

… EGFR mutations responsible for primary or acquired resistance against TKI therapy. , 5 In
addition, many rare EGFR mutations (… 18–21] of EGFR excluding exon 19 microdeletions and …

… Our findings suggested that only patients with rare EGFR mutations could receive platinum-…
and short PFS in response to EGFR-TKIs. Consequently, EGFR-TKIs could be reserved as a …

… The results of this study clearly demonstrate that heterogeneous distribution of an EGFR
mutation in individual tumors is an extremely rare event. This conclusion is also supported by …

… 50% of EGFR mutations, and the exon 21 point mutation at the … of relatively rare EGFR
mutations whose associations to EGFR … rare EGFR mutations and their sensitivity to EGFR TKIs. …

… common and rare forms of EGFR mutations and associated … We have found single or double
EGFR mutations in 200 (43.9… point mutations, exon 20 T790M (1.3%) and other mutations (…

… This report refers to the first multicentre exhaustive study on rare EGFR mutations that was
conducted on a national basis [15]. This kind of collaborative effort involving numerous cancer …

… rare variants, usually missed with available commercial kits that only detect a limited number
of EGFR mutations… multiple EGFR mutations is generally thought to be a relatively rare event…

… EGFR-TKIs (22,23), while it has also been recently involved in resistance to the third …
EGFR inhibitor Osimertinib in EGFR-mutated NSCLC (24). Moreover, the exon 14 skip mutation, …

… This study reviewed the prevalence of uncommon EGFR mutations and their sensitivity to
EGFR… L858R mutations, indicating that they may benefit from EGFR-TKIs as a first-line therapy. …