418P All EGFR mutations are (not) created equal: Focus on uncommon EGFR mutations

U Batra, M Sharma, S Narayan… - Annals of …, 2020 - annalsofoncology.org
… This retrospective study reviews prevalence of these mutations in an Indian NSCLC cohort …
Conclusions: Rare and dual EGFR mutations are a heterogeneous group with distinct clinical …

EGFR tyrosine kinase inhibitor (TKI) in patients with advanced non-small cell lung cancer (NSCLC) harboring uncommon EGFR mutations: A real-world study in China

J Xu, B Jin, T Chu, X Dong, H Yang, Y Zhang, D Wu… - Lung cancer, 2016 - Elsevier
… There are a number of uncommon EGFR mutations whose … uncommon EGFR mutations
and their sensitivity to EGFR TKIs. … We performed a separate analysis of the efficacy of EGFR

Rare versus artifactual EGFR mutations

PM Domingues, T Montella, C Baldotto - Journal of Thoracic Oncology, 2015 - jto.org
… identified 45 rare EGFR mutations in 70 samples of lung tumor DNA extracted from FFPE
tissue, and they were all found to be artifacts. This was confirmed because they also found the …

[HTML][HTML] Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions

GR Oxnard, PC Lo, M Nishino, SE Dahlberg… - Journal of Thoracic …, 2013 - Elsevier
… point mutations), (3) other rare EGFR mutations, and (4) EGFR … Relative prevalence of different
insertions variants found in … Given our prevalence findings, we estimate that lung cancers …

Reply to Rare versus artifactual EGFR mutations

Z Lohinai, G Ostoros, J Moldvay, B Dome… - Journal of Thoracic …, 2015 - jto.org
Distinct epidemiology and clinical consequence of classic versus rare EGFR mutations in …
Therefore, we not only pointed out the possible clinical relevance of rare EGFR mutations but …

Comprehensive analysis of the incidence and survival patterns of lung cancer by histologies, including rare subtypes, in the era of molecular medicine and targeted …

JS Chang, LT Chen, YS Shan, SF Lin, SY Hsiao… - Medicine, 2015 - journals.lww.com
… incidence or mortality rates of rare primary tumors of the lung, … different etiologies for the
various subtypes of lung cancers. Therefore, investigating the epidemiologic patterns of the rare

NSCLC patients harbouring rare or complex EGFR mutations are more often smokers and might not benefit from first-line tyrosine kinase inhibitor therapy

D Kauffmann-Guerrero, RM Huber, S Reu, A Tufman… - Respiration, 2018 - karger.com
… 4 patients showed 2 different mutations in the EGFR. All … rare or complex EGFR mutation.
In contrast to the classic activating mutations, there is only little knowledge of epidemiology

Comprehensive genomic profiling of rare tumors: routes to targeted therapies

S Wang, R Chen, Y Tang, Y Yu, Y Fang… - Frontiers in …, 2020 - frontiersin.org
… To estimate the prevalence of targetable mutations in rare tumors, we queried the … has
a larger population base, and a different epidemiological distribution for most types of tumors …

Outcome of uncommon EGFR mutation positive newly diagnosed advanced non-small cell lung cancer patients: a single center retrospective analysis

S Kate, A Chougule, A Joshi, V Noronha… - Lung Cancer: Targets …, 2019 - Taylor & Francis
… To summarize, uncommon EGFR mutations do constitute a distinct heterogeneous group …
ShiYAuJSThongprasertSA prospective, molecular epidemiology study of EGFR mutations in …

The significance of epidermal growth factor receptor uncommon mutations in non-small cell lung cancer: A systematic review and critical appraisal

V Gristina, U Malapelle, A Galvano, P Pisapia… - Cancer Treatment …, 2020 - Elsevier
… The prevalence of EGFR mutations ranges from 10% to 15% in … EGFR mutations have been
collectively named “uncommon” to be distinguished from the classical sensitizing mutations