… Clearly, no agent is ready for colon cancer chemoprevention in humans, except, perhaps,
calcium and celecoxib. Before 1990, the gold standard end point for chemoprevention in …

… -Dawley rats, we report … colonic epithelia for the chemoprevention of colon cancer. To our
knowledge, this is a first proof-of-concept report using nanotechnology-based chemopreventive …

… Aberrant crypt foci (ACF) are unique preneoplastic markers of colon cancer used to assess
the chemopreventive effect of either a natural or synthetic compound. ACF can be classified …

… Numerous studies have shown the chemopreventive effects of ursodiol in rat models of
carcinogenesis, and the results of human studies are now beginning to emerge Citation[51]. In a …

… the chemopreventive efficacy of squalene on azoxymethane (AOM)-induced colonic … In
addition, we measured the effect of squalene on serum cholesterol levels in the rats. Male …

Our findings reported so far demonstrate that silibinin modulates gut microbial enzymes,
colonic oxidative stress and Wnt/β-catenin signaling, to exert its antiproliferative effect against 1,…

… data do not correlate to actual colon tumor outcome, however, and … -induced rat ACF as
biomarkers in colon cancer chemoprevention … them as biomarkers in chemoprevention studies. …

… investigate the chemopreventive efficacy and dose-response effect of curcumin when … colon
carcinogenesis in F344 rats. In addition, the effect of dietary curcumin on apoptosis in colon …

… We assessed the effects of 41 potential chemopreventive agents in the F344 rat using … colon
as the measure of efficacy. ACF were induced by the carcinogen azoxymethane in F344 rats …

… colon cancer bearing rats treated with hesperetin (as in group 2) for the first 15 weeks (initiation),
group 5 rats were colon cancer bearing rats … 6 rats were colon cancer bearing rats …