San‐HuangXie‐Xin‐tang prevents rat hearts from ischemia/reperfusion‐induced apoptosis through eNOS and MAPK pathways

SF Liou, HJ Ke, JH Hsu, JC Liang… - Evidence‐Based …, 2011 - Wiley Online Library
San‐HuangXie‐Xin‐Tang (SHXT) is a traditional Chinese medication consisting of three
herbs, namely Coptidis rhizome, Scutellariae radix and Rhei rhizome. This study aimed to …

Rolipram, a PDE4 inhibitor, enhances the inotropic effect of rat heart by activating SERCA2a

H Huang, M Xie, L Gao, W Zhang, X Zhu… - Frontiers in …, 2019 - frontiersin.org
This study was designed to investigate the hemodynamic effect of rolipram, a phosphodiesterase
type 4 (PDE4) inhibitor, in normal rat hearts both in vivo and in vitro and its underlying …

Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway

H Xie, J Zhang, J Zhu, L Liu, M Rebecchi… - Acta Pharmacologica …, 2014 - nature.com
… In the present study, we chose 3% sevoflurane to post-condition the isolated rat hearts in
a Langendorff perfusion system 28 . Intracellular mitogen-activated protein kinases (MAPKs) …

An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs

K Huang, EW Ozpinar, T Su, J Tang, D Shen… - Science translational …, 2020 - science.org
… (A) H&E staining was performed on 10-μm cryosections of rat hearts 21 days after MI. Insets
outlined by red dashed boxes are shown at higher magnification in the bottom row. Yellow …

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

…, SW An, M Kuro-o, L Birnbaumer, CL Huang - Nature …, 2012 - nature.com
… We examined the role of Klotho in protecting the heart using Klotho-… heart weight
indices (heart weight normalized to body weight or tibia length) as well as the overall heart

[HTML][HTML] Renalase protects the cardiomyocytes of Sprague-Dawley rats against ischemia and reperfusion injury by reducing myocardial cell necrosis and apoptosis

X Li, Z Xie, M Lin, R Huang, Z Liang, W Huang… - Kidney and Blood …, 2015 - karger.com
rats [11]. Furthermore, we have previously investigated renalase gene polymorphisms in
patients with coronary heart … plays a vital role in the hearts of SD rats and might be beneficial in …

Increased sarcoplasmic/endoplasmic reticulum calcium ATPase 2a activity underlies the mechanism of the positive inotropic effect of ivabradine

M Xie, HL Huang, WH Zhang, L Gao… - Experimental …, 2020 - Wiley Online Library
… The results demonstrated that ivabradine increased the positive inotropy of the rat heart in
vivo by increasing the stroke work, cardiac output, stroke volume, end-diastolic volume, end-…

Cold-inducible RNA-binding protein prevents an excessive heart rate response to stress by targeting phosphodiesterase

D Xie, L Geng, K Xiong, T Zhao, S Wang, J Xue… - Circulation …, 2020 - Am Heart Assoc
… The neonatal rat cardiomyocytes were enzymatically isolated and cultured as described
previously. Briefly, neonatal rat hearts were cut into small pieces and dissociated in cold PBS …

Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion

J Tang, Q Xie, G Pan, J Wang… - European Journal of …, 2006 - academic.oup.com
Objective: The effect of transplanted mesenchymal stem cells (MSCs) on the left ventricular (LV)
function and morphology in a rat myocardial infarct heart with reperfusion model were …

Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy

J Huang, H Huang, W Pan, D Ou… - Molecular …, 2017 - spandidos-publications.com
… After the echocardiographic examination, rats were sacrificed, and hearts from rats in
each group were excised. The heart weight (HW) and the body weight (BW) were obtained …