Real-world validation of molecular international prognostic scoring system for myelodysplastic syndromes

E Sauta, M Robin, M Bersanelli, E Travaglino… - Journal of Clinical …, 2023 - ascopubs.org
Myelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted
treatment strategy is needed. … We aimed to provide an extensive validation of IPSS-M. …

Real-World validation of molecular international prognostic scoring system (IPSS-M) for myelodysplastic syndromes

E Sauta, M Robin, M Bersanelli, E Travaglino… - Blood, 2022 - ashpublications.org
Introduction Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic neoplasms
characterized by peripheral blood cytopenia and increased risk of evolution into acute …

Real-world assessment of myelodysplastic syndrome: Japanese claims data analysis

S Tsutsue, T Suzuki, H Kim, B Crawford - Future Oncology, 2022 - Taylor & Francis
Aim: To describe the treatment landscape and associated economic burden for myelodysplastic
syndrome in Japan. Methods: We studied nationwide retrospective claims data from …

[HTML][HTML] Real-world Effectiveness of Azacitidine in Treatment-Naive Patients With Higher-risk Myelodysplastic Syndromes

N Rajakumaraswamy, M Gandhi, AH Wei… - … Myeloma and Leukemia, 2024 - Elsevier
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies
characterized by clonal hematopoiesis and ineffective blood cell production, resulting in …

[HTML][HTML] Treatment patterns in older patients with myelodysplastic syndromes: A population-based analysis reflecting the real world

J Rozema, J Graafsma, M Hoogendoorn… - Journal of Geriatric …, 2023 - Elsevier
… This study shows the treatment outcomes in a real-world population of older patients with
MDS. Treatment duration and median OS after treatment discontinuation were relatively limited…

Real world data on the prognostic significance of monocytopenia in myelodysplastic syndrome

PT Diamantopoulos, E Charakopoulos… - Scientific Reports, 2022 - nature.com
Validation in other cohorts is still needed. Finally, and most importantly, patients with low, …
Validation of our results in other cohorts will help further define the prognostic role of …

Venetoclax and hypomethylating agent therapy in high risk myelodysplastic syndromes: a retrospective evaluation of a real-world experience

A Azizi, A Ediriwickrema, R Dutta, SA Patel… - Leukemia & …, 2020 - Taylor & Francis
Abstract Treatment with hypomethylating agents (HMAs) azacitidine or decitabine is the
current standard of care for high risk myelodysplastic syndromes (MDSs) but is associated with …

Considerations for drug development in myelodysplastic syndromes

MA Sekeres, N Kim, AE DeZern, KJ Norsworthy… - Clinical Cancer …, 2023 - AACR
… in quality of life as measured by validated PRO tools. … Real-life data consistently show
how clinical outcomes fall … disease, and to the feasibility of using it in the real world (54). …

… personalized risk model for azacitidine outcome in myelodysplastic syndrome and other myeloid neoplasms identified by machine learning model utilizing real-world …

K Sharplin, W Proudman, R Chhetri, ENH Tran… - Cancers, 2023 - mdpi.com
validation cohorts with a 1:1 ratio based on an equal proportion of the IPSS-R. Patient
characteristics for the training cohort and independent validation … model was further validated in an …

Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the …

R Shenolikar, E Durden, N Meyer, G Lenhart… - Gynecologic …, 2018 - Elsevier
Real-world data on patients with cancer developing secondary malignancies such as
myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are lacking. This study …