Antigenicity and receptor affinity of SARS-CoV-2 BA. 2.86 spike
… Because receptor binding also … affinity for the viral receptor compared with the spike of
XBB.1.5 or EG.5.1 (Figs. 4a,b). In fact, BA.2.86 spike has one of the highest receptor affinities we …
XBB.1.5 or EG.5.1 (Figs. 4a,b). In fact, BA.2.86 spike has one of the highest receptor affinities we …
[HTML][HTML] Structural basis of receptor recognition by SARS-CoV-2
… We measured the binding affinities between each of the three RBDs (SARS-CoV-2, … ,
we characterized ACE2-binding affinities of the SARS-CoV-2 spike that contains mutations in …
we characterized ACE2-binding affinities of the SARS-CoV-2 spike that contains mutations in …
[HTML][HTML] Binding affinity and mechanisms of SARS-CoV-2 variants
… SARS-CoV-2 binding affinity caused by these residue mutations. This research identified
the binding affinity differences of the SARS-CoV-… wild-type SARS-CoV-2 spike receptor-binding …
the binding affinity differences of the SARS-CoV-… wild-type SARS-CoV-2 spike receptor-binding …
[HTML][HTML] Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants
C Laffeber, K de Koning, R Kanaar… - Journal of molecular …, 2021 - Elsevier
… affinity for the hACE2 receptor, we purified the hACE2 ectodomain and different SARS-CoV-2
RBD variants from human cells (Figure S2(A)–(D)), and determined rate and affinity …
RBD variants from human cells (Figure S2(A)–(D)), and determined rate and affinity …
Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants
P Han, C Su, Y Zhang, C Bai, A Zheng, C Qiao… - Nature …, 2021 - nature.com
… -2 variant RBDs and hACE2, we measured their binding affinity using surface plasmon
resonance (SPR). Mouse Fc (mFc) tagged hACE2 was captured in a CM5 chip that pre-…
resonance (SPR). Mouse Fc (mFc) tagged hACE2 was captured in a CM5 chip that pre-…
Comparing the binding interactions in the receptor binding domains of SARS-CoV-2 and SARS-CoV
… affinities of the S proteins of SARS-CoV and SARS-CoV-2 to the ACE2. Our results show
that the protein surface of the ACE2 at the receptor … the S proteins of SARS-CoV/SARS-CoV-2. …
that the protein surface of the ACE2 at the receptor … the S proteins of SARS-CoV/SARS-CoV-2. …
Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution
… Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin-…
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin-…
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics
… Here we perform a detailed affinity and kinetics analysis of the … SARS-CoV-2 Alpha (B.1.1.7),
Beta (B.1.351), and Gamma (P1) variants. Most of these mutations increased the affinity of …
Beta (B.1.351), and Gamma (P1) variants. Most of these mutations increased the affinity of …
Molecular basis for higher affinity of SARS‐CoV‐2 spike RBD for human ACE2 receptor
JM Delgado, N Duro, DM Rogers… - Proteins: Structure …, 2021 - Wiley Online Library
… have a much higher affinity for CoV-2 spike RBD compared to CoV spike RBD. Here we
examine the molecular basis underlying the different binding affinities of CoV and CoV-2 spike …
examine the molecular basis underlying the different binding affinities of CoV and CoV-2 spike …
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2
… However, we and others have shown that WT ACE2 binds the SARS-CoV-2 spike RBD
with only modest affinity ( K D ∼ 15 nM) (15–17). ACE2 is therefore a good candidate for …
with only modest affinity ( K D ∼ 15 nM) (15–17). ACE2 is therefore a good candidate for …
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