Death receptor agonists as a targeted therapy for cancer

J Wiezorek, P Holland, J Graves - Clinical cancer research, 2010 - AACR
… threshold sensitivity to apoptotic stimuli, such as Bcl-2 family members and inhibitors of
apoptosis, play an important role in determining a cell's response to DR agonists (12, 21). …

Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

M Huse, LO Klein, AT Girvin, JM Faraj, QJ Li, MS Kuhns… - Immunity, 2007 - cell.com
… We refer to the delay between agonist activation and the subsequent response as the “offset
time,” which can be interpreted as a measurement of signaling speed. These results …

Signal transduction pathways in the mitogenic response to G protein–coupled neuropeptide receptor agonists

E Rozengurt - Journal of cellular physiology, 1998 - Wiley Online Library
… play a role in transducing mitogenic and migratory responses induced by G protein–coupled
neuropeptide receptor agonists. J Cell Physiol 177:507–517, 1998. © 1998 Wiley‐Liss, Inc. …

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands

SM Alam, GM Davies, CM Lin, T Zal, W Nasholds… - Immunity, 1999 - cell.com
agonist ligands) leads to a partial activation of the cell or the inhibition of responses to
coadministered agonist … the complexities of signal transduction through the T cell receptor (TCR) ( …

Overview of the effects of β-adrenergic receptor agonists on animal growth including mechanisms of action

HJ Mersmann - Journal of animal science, 1998 - academic.oup.com
response of a cell type or tissue to a b-AR agonist should depend on the receptor number,
receptors … , and the physiological response usually represents activation of only a few of the …

Agonist-receptor efficacy II: agonist trafficking of receptor signals

T Kenakin - Trends in pharmacological sciences, 1995 - cell.com
responses to an agonist of high efficacy. For example, Costa and colleagues have shown that
the opioid receptor agonist [… adenylate cyclase in NG 108-115 cells 2. Upon decline of the …

Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination

S Ebert, J Gerber, S Bader, F Mühlhauser… - Journal of …, 2005 - Elsevier
… The present study quantifies the activation of microglial cells in response to stimulation
with one or two simultaneously administered specific agonists of TLR2, TLR4, and TLR9 at …

Effects of β-agonists on airway epithelial cells

M Salathe - Journal of allergy and clinical immunology, 2002 - Elsevier
… The first step in understanding airway epithelial cell responses to β-agonists was to evaluate
which cells in the superficial airway epithelium and in submucosal glands express βARs. …

Toll-like receptor agonists in cancer therapy

S Adams - Immunotherapy, 2009 - Taylor & Francis
receptor agonists represent promising vaccine adjuvants as they are potent DC activators,
augment T-cell responses … the clinical development of TLR agonists as vaccine adjuvants for …

Glutamate receptor agonists stimulate diverse calcium responses in different types of cultured rat cortical glial cells

JA Holzwarth, SJ Gibbons, JR Brorson… - Journal of …, 1994 - Soc Neuroscience
responses to glutamate receptor agonists We examined the effects of different types of
glutamate receptor agonists on [Ca*+], in cells … glutamate receptor-mediated [Ca2+], responses