… We sought to develop mouse models of sterile injury to determine innate elements that
recognize and mediate sterile inflammation. Our results demonstrate that the initiation of a sterile …

… and receptor pathways that result in sterile inflammation and … of biologically active cytokines
during sterile injury-associated cell … release of cytokines during sterile cell injury has a role in …

… then be recognized by what is called a prototypic DAMP receptor: the multi-ligand receptor
RAGE. This DAMP receptor activation leads to the activation of several signaling pathways …

… Classically considered a wound healing response, the inflammatory reaction to sterile injury
… at sites of sterile injury, and they possess a number of functional receptors that may allow …

… been shown to activate the fMLP receptor, allowing neutrophils to localize with bacteria.
Surprisingly, the fMLP receptor also directs neutrophils to the site of sterile injury. Indeed, lysis of …

… HMGB1 interacts with a number of receptors including toll-like receptor 2 (TLR2), TLR9 and
… of sterile injury and we would argue that trauma is quite different from sterile injury caused …

… Over the past 20 years, numerous new DAMP-receptor axes have been discovered in
various injury scenarios. Here we focus on the receptors that sense DAMPs, in order to discuss …

… to sterile injuries. Accordingly, we suggest that the insufficient axonal regeneration and
cell renewal in the CNS do not reflect an overall lack of repair capacity, but the insufficient …

… Regarding the later phases of inflammation, treatment with the receptor tyrosine kinase
inhibitor nilotinib was shown to ameliorate hepatic I/R injury in mice by inhibiting the pro-…

… While sterile injury and pathogen-induced reactions may … by examining the expression of
receptors for DAMPs, RAMPs, and … The C1q-HMGB1 complex activates the LAIR receptor of …