[HTML][HTML] The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex
SA Jones, S Rose-John - Biochimica et Biophysica Acta (BBA)-Molecular …, 2002 - Elsevier
… the activities of the soluble IL-6 receptor (sIL-6R) (see below). Although IL-6R expression
is largely confined to hepatocytes and sub-populations of leukocytes, IL-6 bioactivity can also …
is largely confined to hepatocytes and sub-populations of leukocytes, IL-6 bioactivity can also …
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
S Rose-John, GH Waetzig, J Scheller… - Expert opinion on …, 2007 - Taylor & Francis
… the membrane-bound type of receptor (mIL-6R) Citation[11,… sIL-6R does not antagonise
IL-6 function. In contrast to most other cytokine receptors, a complex comprising IL-6 and sIL-6R …
IL-6 function. In contrast to most other cytokine receptors, a complex comprising IL-6 and sIL-6R …
Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases
S Nikolaus, GH Waetzig, S Butzin, M Ziolkiewicz… - International journal of …, 2018 - Springer
… Interleukin-6 (IL-6) production and … IL-6 and its soluble receptors sIL-6R and sgp130 in IBD
are from small cohorts and partly contradictory, we systematically evaluated IL-6, sIL-6R and …
are from small cohorts and partly contradictory, we systematically evaluated IL-6, sIL-6R and …
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane …
M Narazaki, K Yasukawa, T Saito, Y Ohsugi, H Fukui… - 1993 - ashpublications.org
… sIL-6R when rIL-6 is added. We further indicate that natural sgpl30 contained in human serum
inhibits the IL-6 action mediated by serum sIL6R… a signal transducing receptor component. …
inhibits the IL-6 action mediated by serum sIL6R… a signal transducing receptor component. …
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
SA Jones, S Horiuchi, N Topley… - The FASEB …, 2001 - Wiley Online Library
… soluble interleukin 6 receptor (sIL-6R), which forms a ligand–receptor complex with IL-6
that is … Elevated sIL-6R levels have been documented in numerous clinical conditions indicating …
that is … Elevated sIL-6R levels have been documented in numerous clinical conditions indicating …
Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses
G Muller-Newen, A Kuster, U Hemmann… - The Journal of …, 1998 - journals.aai.org
… that sIL-6R acts agonistically by enhancing the effects of IL-6, … Since soluble forms of both
receptor components (sIL-6R (21… is able to efficiently bind IL-6/sIL-6R complexes. To study its …
receptor components (sIL-6R (21… is able to efficiently bind IL-6/sIL-6R complexes. To study its …
[HTML][HTML] High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130.
LD Ward, GJ Howlett, G Discolo, K Yasukawa… - Journal of Biological …, 1994 - Elsevier
… analysis, in the low affinity receptor complex, IL-6 was shown to bind sIL-6R in a … -6, sIL-6R,
and sgp-130. This is the first direct demonstration of a higher order arrangement for receptor …
and sgp-130. This is the first direct demonstration of a higher order arrangement for receptor …
Serum soluble interleukin‐6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin‐6 signal
H Suzuki, K Yasukawa, T Saito… - European journal of …, 1993 - Wiley Online Library
… sIL-6R in the sera from MRL/lpr mice could mediate the IL-6 functions through the IL-6
signal-transducing receptor component gpt30, suggesting that elevated production of sIL-6R may …
signal-transducing receptor component gpt30, suggesting that elevated production of sIL-6R may …
IL-6 receptor and mechanism of signal transduction
T Kishimoto, S Akira, T Taga - International journal of …, 1992 - Elsevier
… BAFB03 and BAF130-9 cells were metabolically radiolabeled and stimulated with
soluble IL-6R plus IL-6, or soluble ILdR alone, and lysed with digitonin-lysis buffer. …
soluble IL-6R plus IL-6, or soluble ILdR alone, and lysed with digitonin-lysis buffer. …
Soluble interleukin-6 receptor (sIL-6R) in cerebrospinal fluid of patients with inflammatory and non inflammatory neurological diseases
M Michalopoulou, C Nikolaou, A Tavernarakis… - Immunology letters, 2004 - Elsevier
… IL-4, TNFa and their soluble receptors, and thus the measurement of total soluble IL-6R (free
sIL-6R plus the amount of soluble receptor bound to IL-6) may give more reproducible and …
sIL-6R plus the amount of soluble receptor bound to IL-6) may give more reproducible and …
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