… the activities of the soluble IL-6 receptor (sIL-6R) (see below). Although IL-6R expression
is largely confined to hepatocytes and sub-populations of leukocytes, IL-6 bioactivity can also …

… the membrane-bound type of receptor (mIL-6R) Citation[11,… sIL-6R does not antagonise
IL-6 function. In contrast to most other cytokine receptors, a complex comprising IL-6 and sIL-6R …

… Interleukin-6 (IL-6) production and … IL-6 and its soluble receptors sIL-6R and sgp130 in IBD
are from small cohorts and partly contradictory, we systematically evaluated IL-6, sIL-6R and …

… sIL-6R when rIL-6 is added. We further indicate that natural sgpl30 contained in human serum
inhibits the IL-6 action mediated by serum sIL6R… a signal transducing receptor component. …

… soluble interleukin 6 receptor (sIL-6R), which forms a ligand–receptor complex with IL-6
that is … Elevated sIL-6R levels have been documented in numerous clinical conditions indicating …

… that sIL-6R acts agonistically by enhancing the effects of IL-6, … Since soluble forms of both
receptor components (sIL-6R (21… is able to efficiently bind IL-6/sIL-6R complexes. To study its …

… analysis, in the low affinity receptor complex, IL-6 was shown to bind sIL-6R in a … -6, sIL-6R,
and sgp-130. This is the first direct demonstration of a higher order arrangement for receptor …

… sIL-6R in the sera from MRL/lpr mice could mediate the IL-6 functions through the IL-6
signal-transducing receptor component gpt30, suggesting that elevated production of sIL-6R may …

… BAFB03 and BAF130-9 cells were metabolically radiolabeled and stimulated with
soluble IL-6R plus IL-6, or soluble ILdR alone, and lysed with digitonin-lysis buffer. …

… IL-4, TNFa and their soluble receptors, and thus the measurement of total soluble IL-6R (free
sIL-6R plus the amount of soluble receptor bound to IL-6) may give more reproducible and …