… growth factor receptor (EGFR) responds to EGFR tyrosine kinase inhibitors such as erlotinib…
However, secondary somatic EGFR mutations (eg, T790M) confer resistance to erlotinib. …

… with increased gefitinib and erlotinib sensitivity in patients with … of the EGFR tyrosine kinase
inhibitors gefitinib and erlotinib. … inhibitors of CYP3A4 activity decrease gefitinib and erlotinib …

… factor receptor inhibitor erlotinib are low … erlotinib. Methods: Twenty-two patients (6 men,
16 women; mean age ± SD, 64 ± 13 y) with stage III or stage IV NSCLC who received erlotinib …

… KIP1 in G 1 /S arrest and cell growth inhibition by erlotinib, we determined its effect on the …
that erlotinib treatment resulted in the promotion of p27 gene transcription. In addition, erlotinib …

… through inhibition of angiogenic growth factor production, inhibition of invasion … receptor
activation and small-molecule inhibitors of EGFR tyrosine kinase, such as gefitinib and erlotinib, …

… -Akt-mTOR pathways and sensitivity to growth inhibition in a group of 22 cell lines derived
from … We find that erlotinib could inhibit the phosphorylation of Akt, S6, and Erk only in erlotinib-…

… The results of this study indicate that although increasing doses of erlotinib correlate
positively with inhibition of receptor activation and downstream signaling, these effects are not …

… We find that erlotinib could inhibit the phosphorylation of HER-3 in erlotinib-sensitive …
Further, we find that erlotinib could inhibit the Raf-MAPK/ERK kinase-ERK signaling cascade in …

… To assess altered sensitivity to erlotinib, the growth-inhibitory effects of erlotinib on …
erlotinib inhibited Akt activity in both CDDP-sensitive/erlotinib-resistant, and CDDP-resistant/erlotinib…

… Erlotinib-dependent inhibition of EGFR … for erlotinib inhibition (legend) of ligand-dependent
receptor activation for each of the NR6-EGFR cell lines. Points, mean decrease in receptor …