… brain metastasis (BM) is high in patients with non-small-cell lung cancer. Available standard
therapeutic options, such as whole-brain … as EGF receptor (EGFR) tyrosine kinase inhibitors (…

… Brain metastases are a common and devastating consequence of … receptor (EGFR) inhibitors
erlotinib and gefitinib have shown efficacy in patients with NSCLC and brain metastases. …

… and documented measurable brain metastases. Prior local therapy to metastatic brain tumors,
… with asymptomatic or controlled symptomatic brain metastases by corticosteroid only were …

… , including WBRT, stereotactic radiosurgery, or surgery, for brain metastases. If a patient did
not receive local therapy for brain metastases, that patient was censored at the date of death …

… status at the time of brain metastases, number of brain metastases, size of largest brain
metastasis, whether the patient was symptomatic from brain metastases, type of RT delivered, …

… brain barrier, and hold the promise for more effective prevention and treatment of brain
metastases… In this article we review the role of currently available or investigational HER2 tyrosine …

… included diverse brain metastases settings : brain metastases at first diagnosis of NSCLC,
brain metastases relapse after curative surgery, and new development of brain metastases on …

… -mutant non-small-cell lung cancer patients under tyrosine kinase … of brain metastases
in epidermal growth factor receptor-mutant non-small-cell lung cancer patients under tyrosine …

… Metastatic NSCLC is difficult to treat in general, and median overall … brain metastasis at the
time of diagnosis of the primary lesion have worse survival than those with a brain metastasis …

… “Recurrent responses to non-small-cell lung cancer brain metastases with erlotinib”, we …
with brain metastasis and three subsequent responses to EGFR tyrosine kinase inhibitors (…