… MTX-binding protein was the same hydrophobic folate receptor involved in the uptake of
5-… forms within the internal milieu of KB cells that constitutively overexpress folate receptors. …

… biology of these receptor complexes. This chapter will review nAChR medicinal chemistry
… the existence of discrete receptor subtypes and their relationship to physiological disorders. …

… of drugs which are pharmacologically effective at a particular receptor should displace the
… effective concentrations of drugs acting at different receptors should be ineffective. Known …

… drugs that block the action of the b‑adrenergic receptor (bARs) and the H2 histamine receptor,
… Buck were the recipients of the 2004 Prize for their work on odorant receptors and the …

… A2-adenosine receptors. Characterization of the ATP receptor and the adenosine receptors
has … Certain of the biologically active ATP analogues are proving particularly valuable, since …

… and nuclear receptor drug discovery should lead to highly effective and specific drugs for the
… The present volume comprehensively treats nuclear receptors from the medicinal chemistry …

… From leads to drugs: G-protein-coupled receptors (GPCRs) have historically been … drug
discovery programs. Nowadays many drugs on the market modulate the action of this receptor …

… the drug effectively from its biological receptor. These findings also implicate the
immunophilin-drug … Although a role for FKBP as the mediator of the biological actions of rapamycin …

… the function of these receptors should provide a mechanistic basis for drug interactions in
which one drug alters the metabolism of another. Interestingly, the human SXR receptor and its …

… receptor target. However, as we will see later (see section on dual receptor antagonists), drugs
… , be desirable and there are examples of drugs that target more than one GPCR, which is …