… mouse models of sterile injury and explored the role of hyaluronan in mediating inflammation
following injury. The response of cultured monocytes to hyaluronan was different than the …

… Components of the extracellular matrix such as hyaluronan are … if hyaluronan fragments
released following injury can … Using genechip microarray analysis, a response to hyaluronan …

… be particularly relevant in settings of sterile inflammation. … as a form of pattern recognition
that distinguishes between tissue … regulation are integrated in injured and healing tissues. …

… hyaluronan accumulates during tissue injury and functions in ways distinct from the native
polymer. There is accumulating evidence that hyaluronan … cells at the injury site. CD44 is the …

… DAMPs recognized by CD44 and P2X7 are hyaluronan and … The function of peritoneal
macrophages in sterile injury is … However, peritoneal macrophages recruited to sterile liver injury …

… The initiation of a sterile intrinsic inflammatory event induces HA accumulation at … injury has
been proposed to involve recognition of components of damaged cells by pattern recognition …

… together in the lung and are altered in response to injury. However from the reports
published thus far hyaluronan may offer a therapeutic benefit as a treatment in acute lung injury. …

… , elements of the hyaluronan recognition process were … sterile intrinsic inflammatory process
is dependent on TLR4 activation, (b) sterile injury induces HA accumulation at the injured …

… The association of increased HA deposition into the extracellular matrix (ECM) after tissue
injury and during inflammatory disease has been recognized for over 25 years. Increased …

… with pathogens and following tissue injury can be recognized by innate immune receptors. …
under conditions of sterile inflammation, we examined the role of TLR signaling in the injury, …