Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures

M Olsson, L Bremer, C Aulin, HE Harris - Innate Immunity, 2018 - journals.sagepub.com
Hyaluronan (HA) is a large polymer and an important component of the extracellular matrix.
During homeostasis, high molecular mass HA is the predominant form, but upon …

Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.

CM McKee, MB Penno, M Cowman… - The Journal of …, 1996 - Am Soc Clin Investig
… , but it has since been recognized as the receptor for the complex of … Molecular cloning of a
novel hyaluronan receptor that … aortic smooth muscle cells after wounding injury. The role of …

Identification of the hyaluronan receptor for endocytosis (HARE)

B Zhou, JA Weigel, LA Fauss, PH Weigel - Journal of Biological Chemistry, 2000 - ASBMB
… Rat liver sinusoidal endothelial cells (LECs) express two hyaluronan (HA) receptors, of 175
… The 97-kDa subunit was not recognized by any of the mAbs in Western blots. Based on their …

Hyaluronan up-regulates growth and invasion of trophoblasts in an autocrine manner via PI3K/AKT and MAPK/ERK1/2 pathways in early human pregnancy

R Zhu, YH Huang, Y Tao, SC Wang, C Sun, HL Piao… - Placenta, 2013 - Elsevier
Introduction As one of the key molecules in the extracellular matrix in human conceptus,
hyaluronan (HA) has been receiving particular attention. Here, we have investigated the …

Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity

A Hoarau, M Polette, C Coraux - Biomolecules, 2022 - mdpi.com
… Their production is regulated by the transmembrane enzymes hyaluronan synthases (HAS). …
and waste products into the site of injury. Several important functions associated with HA …

[PDF][PDF] Toll-Like Receptor 2 Dependent Signaling of Low Molecular Weight Hyaluronan Upregulates T-Helper 17 Differentiation and Promotes the Expression of …

KM Woodman - 2017 - core.ac.uk
… pattern recognition receptors … hyaluronan, a structural polysaccharide found in the extracellular
matrix. We initially hypothesized that low molecular weight hyaluronan, indicative of injury

Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein A …

JP Foley, D Lam, H Jiang, J Liao, N Cheong… - Journal of Biological …, 2012 - ASBMB
… roles in regulation of host defense via recognition of specific pathogen-associated molecular
… after bleomycin injury, suggesting that HA is critical in macrophage recruitment to the lung ( …

CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling

Y Iwata, A Yoshizaki, K Komura, K Shimizu… - The American journal of …, 2009 - Elsevier
… Collectively, the influence of HA on B cell functions would provide novel mechanisms
how CD19 expression affects wound healing process: under the sterile injury, increased HA …

35kDa hyaluronan ameliorates ethanol driven loss of anti-microbial defense and intestinal barrier integrity in a TLR4-dependent manner

S Ray, E Huang, GA West, M Mrdjen, MR McMullen… - Matrix Biology, 2023 - Elsevier
… protecting the gastrointestinal tract but also other organs from alcohol-associated injury. For
instance, in murine models of ALD, liver injury is reduced by restoring C-type lectin AMPs [11…

Cardiac hyaluronan synthesis is critically involved in the cardiac macrophage response and promotes healing after ischemia reperfusion injury

A Petz, M Grandoch, DJ Gorski, M Abrams… - Circulation …, 2019 - Am Heart Assoc
… An interesting candidate ECM system in this regard is hyaluronan (HA). HA is a … , 13 and
autoimmune 14 diseases, it has been recognized that HA strongly affects immune responses. …