… Furthermore, a novel alternative recognition complex is defined, involving the contribution
of TLR4, MD-2, and CD44. Additionally, this unique receptor complex and downstream …

… unique activation pathways mediated by these receptors greatly expand the spectrum of HA
action. CD44, the best characterized of all HA receptors, … isoforms with distinct functions that …

… from the large number of hyaluronan-binding proteins (often … molecular basis of hyaluronan
recognition by proteins and … has been clearly identified as a hyaluronan receptor is LYVE-1. …

… of the receptor that differ in orientation of a crucial hyaluronan-… involved in HA recognition
in the type B crystal complex. (d) … It should be noted that this transition is distinct from the HA-…

… protein has properties distinct from the BHK receptor. The second putative receptor was iirst
… is in the length of HA oligosaccharide required for recognition by the HABPs. Link protein, …

… creation of unique receptor•HA complexes activated for … for creating oligomeric receptor•HA•receptor
complexes in … CD] n complexes create new binding interfaces recognized by …

… HMW-HA interacts with surface receptors, prevents immune cell recognition, and blocks …
clear that HA polymers of specific sizes contain distinct biological activities. HA exists as both a …

… This multiplicity of terminology is derived from the fact that these proteins had been studied
independently by different laboratories in distinct functional contexts, such as lymphocyte …

… However, HA is now recognized as a … endocytic hyaluronan receptor in rat liver sinusoidal
endothelial cells is Ca (þ2)-independent and distinct from a Ca (þ2)-dependent hyaluronan …

… It is recognized that some proteins fit into either category and these will be noted. … Given the
wide distribution of HA, HABP and HAR and the apparent redundancy of distinct proteins that …