… factors have been cloned, and recombinant forms ofthe proteins produced and purified. The
recombinant … Recent data on the biological activities ofseveral highly purified recombinant …

… The avail ability of recombinant hemopoietic growth factors purified from animal or yeast
cell conditioned medium or bacteria has facilitated in vivo experiments, as well as the clinical …

… has provided a number of hemopoietic growth factors that are now … of hemopoietic growth
factors activity, and on recent clinical data. … Recombinant human hemopoietic growth factors …

… recombinant DNA techniques, hemopoietic growth factors (HGFs) have become available for
clinical use and have ameliorated hemopoietic … to restore the hemopoietic response of older…

… Three recombinant hematopoietic growth factors-GCSF (… Recombinant G-CSF is a
lineage-specific growth factor that regulates the production and function of neutrophils. Recombinant …

… The biologic specificities of these factors are highly complex, dose dependent, and … hi the
cloning of hematopoietic growth factor genes and the availability of recombinant material have …

… of recombinant interleukin (IL)-3, IL-6, stem cell factor (SCF), and leukemia inhibitory factor
(LIF) on megakaryocyte (MK) growth, … of growth factors to maximize megakaryocytopoiesis. …

Recombinant human hematopoietic growth factors (HPGF) are now available in quantities
sufficient for use in clinical trials. While at present their Mayn application in clinical oncology is …

… of maturation of all of the hemopoietic lineages, with the exception … growth factors results in
a plating efficiency much less than 10% of that achieved with a combination of all of the factors…

… for investigating the regulation of hemopoiesis at a cellular level. This will be particularly
relevant as more highly purified and recombinant human growth factors become available. The …