Recruiting T cells in cancer immunotherapy
… of T cell dynamics suggest that the T cell response to immune checkpoint blockade (ICB) may
originate outside the tumor and rely on peripheral T cell recruitment. … treatment regimens. …
originate outside the tumor and rely on peripheral T cell recruitment. … treatment regimens. …
Cancer immunotherapy: the past, the present and the future
CR Parish - Immunology and cell biology, 2003 - Wiley Online Library
… the changing attitudes to cancer immunotherapy during the last … the difficulties associated
with immunotherapy of malignancy. … self-reactive T cells in the periphery could be recruited to …
with immunotherapy of malignancy. … self-reactive T cells in the periphery could be recruited to …
Enhancing tumor T cell infiltration to enable cancer immunotherapy
… T cell access to the tumor site. We focus on current strategies to improve cancer immunotherapies
through enhancing T cell … of chemotactic chemokines that recruit T cells [Citation31], …
through enhancing T cell … of chemotactic chemokines that recruit T cells [Citation31], …
Designing cancer immunotherapies that engage T cells and NK cells
O Kyrysyuk, KW Wucherpfennig - Annual review of immunology, 2023 - annualreviews.org
… between NK cell and T cell responses in tumors: NK cells recruit and … T cell–mediated
tumor immunity. In solid tumors, T cells tend to be significantly more abundant than NK cells…
tumor immunity. In solid tumors, T cells tend to be significantly more abundant than NK cells…
… the recruitment, engagement, and reinvigoration of effector T cells via an injectable hydrogel with a supramolecular binding capability for cancer immunotherapy
Y Zhu, L Jin, J Chen, M Su, T Sun… - Advanced Materials, 2023 - Wiley Online Library
… the activation and antitumor functionality of recruited T cells were promoted in tumor tissue
after treatment. The immunophenotype of tumorinfiltrating CD8+ T cells was evaluated as they …
after treatment. The immunophenotype of tumorinfiltrating CD8+ T cells was evaluated as they …
Regulatory T cells: a potential target in cancer immunotherapy
K Shitara, H Nishikawa - Annals of the New York Academy of …, 2018 - Wiley Online Library
… Interaction with chemokines and their receptors is reported to recruit T reg cells into TILs,
such as CCR4 with CCL22, CCR4 with CCL17, CCR10 with CCL28, and CXCR4 with CXCL1.…
such as CCR4 with CCL22, CCR4 with CCL17, CCR10 with CCL28, and CXCR4 with CXCL1.…
Engineered T cells: the promise and challenges of cancer immunotherapy
… Similar to the endogenous natural T cell receptor (TCR) shown on the left, most … rely on
recruitment of endogenous downstream signalling molecules such as linker for activation of T cell …
recruitment of endogenous downstream signalling molecules such as linker for activation of T cell …
T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy
… Furthermore, altered proteolytic processing of CXCL11, an important chemokine recruiting
CXCR3 + effector T cells, can impair binding and signaling of the chemokine, ultimately …
CXCR3 + effector T cells, can impair binding and signaling of the chemokine, ultimately …
In Situ Dendritic Cell Recruitment and T Cell Activation for Cancer Immunotherapy
… enabling the effective treatment of solid tumors are still greatly demanded. Here …
immunotherapy that enables simultaneous recruitment of dendritic cells and in situ activation of T …
immunotherapy that enables simultaneous recruitment of dendritic cells and in situ activation of T …
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
… and non-immune cells. There has recently been a huge amount of research on cancer
immunology and immunotherapy … The recruitment of effector T cells and natural killer cells. CD8 + …
immunology and immunotherapy … The recruitment of effector T cells and natural killer cells. CD8 + …
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