Recruiting T cells in cancer immunotherapy

KE Yost, HY Chang, AT Satpathy - Science, 2021 - science.org
… of T cell dynamics suggest that the T cell response to immune checkpoint blockade (ICB) may
originate outside the tumor and rely on peripheral T cell recruitment. … treatment regimens. …

Cancer immunotherapy: the past, the present and the future

CR Parish - Immunology and cell biology, 2003 - Wiley Online Library
… the changing attitudes to cancer immunotherapy during the last … the difficulties associated
with immunotherapy of malignancy. … self-reactive T cells in the periphery could be recruited to …

Enhancing tumor T cell infiltration to enable cancer immunotherapy

J Zhang, S Endres, S Kobold - Immunotherapy, 2019 - Taylor & Francis
T cell access to the tumor site. We focus on current strategies to improve cancer immunotherapies
through enhancing T cell … of chemotactic chemokines that recruit T cells [Citation31], …

Designing cancer immunotherapies that engage T cells and NK cells

O Kyrysyuk, KW Wucherpfennig - Annual review of immunology, 2023 - annualreviews.org
… between NK cell and T cell responses in tumors: NK cells recruit and … T cell–mediated
tumor immunity. In solid tumors, T cells tend to be significantly more abundant than NK cells

… the recruitment, engagement, and reinvigoration of effector T cells via an injectable hydrogel with a supramolecular binding capability for cancer immunotherapy

Y Zhu, L Jin, J Chen, M Su, T Sun… - Advanced Materials, 2023 - Wiley Online Library
… the activation and antitumor functionality of recruited T cells were promoted in tumor tissue
after treatment. The immunophenotype of tumorinfiltrating CD8+ T cells was evaluated as they …

Regulatory T cells: a potential target in cancer immunotherapy

K Shitara, H Nishikawa - Annals of the New York Academy of …, 2018 - Wiley Online Library
… Interaction with chemokines and their receptors is reported to recruit T reg cells into TILs,
such as CCR4 with CCL22, CCR4 with CCL17, CCR10 with CCL28, and CXCR4 with CXCL1.…

Engineered T cells: the promise and challenges of cancer immunotherapy

AD Fesnak, CH June, BL Levine - Nature reviews cancer, 2016 - nature.com
… Similar to the endogenous natural T cell receptor (TCR) shown on the left, most … rely on
recruitment of endogenous downstream signalling molecules such as linker for activation of T cell

T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy

I Melero, A Rouzaut, GT Motz, G Coukos - Cancer discovery, 2014 - AACR
… Furthermore, altered proteolytic processing of CXCL11, an important chemokine recruiting
CXCR3 + effector T cells, can impair binding and signaling of the chemokine, ultimately …

In Situ Dendritic Cell Recruitment and T Cell Activation for Cancer Immunotherapy

J Han, R Bhatta, Y Liu, Y Bo, H Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
… enabling the effective treatment of solid tumors are still greatly demanded. Here …
immunotherapy that enables simultaneous recruitment of dendritic cells and in situ activation of T

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

N Nagarsheth, MS Wicha, W Zou - Nature Reviews Immunology, 2017 - nature.com
… and non-immune cells. There has recently been a huge amount of research on cancer
immunology and immunotherapy … The recruitment of effector T cells and natural killer cells. CD8 + …