… In the present work we have tried to summarize what is known about the redox biology of
T. cruzi in the context of trypanothione metabolism and oxidant detoxification, the molecules …

… Trypanosoma and Leishmania, which annually affect half a million people around the world
(WHO; http://www.who.int/en/ ). Trypanosoma cruzi … the redox biology of Trypanosoma cruzi: …

… It is estimated that 6–7 million people are infected with Trypanosoma cruzi (T. cruzi), and
~300,000 new cases of ChD emerge each year that account for >10,000 deaths per year 1 …

… Trypanosoma cruzi proliferate and differentiate inside different compartments of triatomines
gut that is the first environment encountered by T. … Additionally, the presence of T cruzi in the …

… Proposed reactions catalyzed by TcrGrx in the redox metabolism of T cruzi. In this system,
reduced trypanothione can transfers reduction equivalents to compounds for detoxification [12]…

… The medically important species, Trypanosoma brucei, Trypanosoma cruzi and Leishmania,
have a digenetic life cycle that alternates between the mammalian host and insect vector. …

… BMitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates
with … Mitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates …

… redox biology is the fact that many parasitic lineages possess distinct and streamlined redox
… Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease. Antioxid …

… redox regulation [16, 17]. Indeed, redox processes have fundamental implications in biology…
In addition to ROS, other reactive species have notable impacts on redox biology, including …

… of the biology of T. cruzi. In addition, the rational development of new drugs against …
the presence of trypanothione, which has therefore a central role in redox metabolism in T. …