Redox regulation and oxidant activation of heme oxygenase-1

R Tyrrell - Free radical research, 1999 - Taylor & Francis
heme oxygenase in protection of skin fibroblasts is probably an emergency inducible defense
pathway to remove heme … of UVA radiation, heme oxygenase levels are constitutively high (…

Redox regulation of heme oxygenase-2 and the transcription factor, Rev-Erb, through heme regulatory motifs

AS Fleischhacker, EL Carter… - Antioxidants & Redox …, 2018 - liebertpub.com
… Structural insight into HRM-mediated redox regulation of heme binding to nuclear receptor,
Rev-erbβ. (A) Structure of the Rev-erbβ LBD in complex with Fe 3+ -heme (holo-LBD, PDB: …

Regulation of heme oxygenase-1 by redox signals involving nitric oxide

R Motterlini, CJ Green, R Foresti - Antioxidants and Redox Signaling, 2002 - liebertpub.com
… Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in …
Redox regulation and oxidant activation of heme oxygenase-1. Free Radic Res 31: 335–340…

Gene regulation of heme oxygenase-1 as a therapeutic target

S Immenschuh, G Ramadori - Biochemical pharmacology, 2000 - Elsevier
… This review summarizes recent advances in the understanding of regulatory mechanisms
of HO-1 gene expression, in particular the role of various redox-dependent and redox-…

The C-terminal heme regulatory motifs of heme oxygenase-2 are redox-regulated heme binding sites

AS Fleischhacker, A Sharma, M Choi, AM Spencer… - Biochemistry, 2015 - ACS Publications
Heme oxygenase-2 (HO2), an enzyme that catalyzes the conversion of heme to biliverdin,
contains three heme regulatory motifs (HRMs) centered at Cys127, Cys265, and Cys282. …

Heme oxygenase-1 signaling and redox homeostasis in physiopathological conditions

V Consoli, V Sorrenti, S Grosso, L Vanella - Biomolecules, 2021 - mdpi.com
… The heme oxygenases (HO) other than provide for heme degradation also participate in
cellular defense. It was observed that the activation of HO-1 is a ubiquitous cellular response to …

Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance

V Calabrese, AMG Stella, DA Butterfield… - Antioxidants & Redox …, 2004 - liebertpub.com
… Recently, the involvement of the heme oxygenase (HO) pathway in antidegenerative …
Redox regulation and oxidant activation of heme oxygenase-1. Free Radic Res 31: 335–340…

Approaches to define pathways of redox regulation of a eukaryotic gene: the heme oxygenase 1 example

RM Tyrrell - Methods, 1997 - Elsevier
… auHeme oxygenase 1 is a heme catabolic enzyme that is … acterization of this gene as redox
regulated: (i) lowering the … to the gene for human heme oxygenase 1, by comparison with a ro…

Regulation and role of heme oxygenase in oxidative injury

PA Dennery - Current topics in cellular regulation, 2001 - Elsevier
… In the 1-week old rats, the observed lack of transcriptional regulation could be … for redox
regulation of lung HO-1 (68). We speculate that oxidative tone influences hyperoxic regulation of …

Evidence that the heme regulatory motifs in heme oxygenase-2 serve as a thiol/disulfide redox switch regulating heme binding

L Yi, SW Ragsdale - Journal of Biological Chemistry, 2007 - ASBMB
Heme oxygenase (HO) catalyzes the O 2 - and NADPH-dependent conversion of heme to
biliverdin, CO, and iron. The two forms of HO (HO-1 and HO-2) share similar physical …