… with diminished striatal dopamine D2 receptor (D2R) availability, likely reflecting their
decreased … D2Rs are also expressed presynaptically on dopamine terminals and on cholinergic …

… dopaminergic hypofunction. Positron emission tomography findings show that a low dopamine
D2 … either a low density of dopamine D2 receptors or a high synaptic concentration of …

… diminished in mice lacking functional dopamine D 2 receptors, whereas their locomotor
depressant response to a dopamine D 1 … These results demonstrate the importance of dopamine …

… (d) Proposed model of reward encoding in the D2 pathways: with increased reward
association strength the D2DRs are internalized, reducing the inhibitory effect of dopamine (red …

… by the adenosine receptor antagonist caffeine was significantly less pronounced in D 2 R
−/… 2 R reduces coupling of A 2A Rs on striatopallidal neurons and thereby responses to drugs …

… induced a higher decrease in striatal dopamine level in D2L -/- than in WT mice (genotype
effect F (1,9) = 6.01, P < 0.03). 0.2 mg kg -1 quinpirole similarly decreased dopamine levels in …

… of the non-selective dopamine agonist apomorphine reduces response latencies of rats to
… (icv) administration of apomorphine reduces the number of writhes in a model of visceral …

… in learning has been less forthcoming, especially in humans. … determined lower density of
striatal DA D2 receptors. This is … role of postsynaptic DA D2 receptors in motivational aspects …

… In this phase, both D2 mutants and haloperidol-treated wild type exhibited significantly lower
response accuracies relative to wild type (wild type versus D2 mutants: P<0.001, wild type …

… EGFP NAcInd mice reduced their responding sooner than the D2R-OE NAcInd mice and the
performance difference between the two groups was measurable at a lower ratio when free …