Spatial heterogeneity of lung strain and aeration and regional inflammation during early lung injury assessed with PET/CT

G Motta-Ribeiro, T Winkler, S Hashimoto, MFV Melo - Academic radiology, 2019 - Elsevier
Spatial heterogeneity of lung aeration and strain (change volume/resting volume) occurs
at … or large regions-of-interest. Spatial heterogeneity could also influence regional gene …

Measures of spatial heterogeneity in the liver tissue micro-environment as predictive factors for fibrosis score

A Agten, A Blázquez-Moreno, M Crabbe… - Computers in Biology …, 2023 - Elsevier
… values (a z-score close to 0) indicate regions where there is no significant spatial clustering.
… An HBsAg-positive hotspot for example indicates a region on the biopsy where significantly …

Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions

JS Brenner, K Bhamidipati, PM Glassman… - … , Biology and Medicine, 2017 - Elsevier
… of inflammation, with patches of inflamed tissue adjacent to … the spatial heterogeneity of
the inflammatory lung disease … were shunted away from inflamed lung regions due to hypoxic …

Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep

ELV Costa, G Musch, T Winkler… - The Journal of the …, 2010 - pubs.asahq.org
… Settings used clinically might be associated with regional inflammation of different intensity
… , marked spatially heterogeneous increases in pulmonary neutrophilic inflammation result …

Exploring spatial heterogeneity of immune cells in nasopharyngeal cancer

A Sobti, C Sakellariou, JS Nilsson, D Askmyr, L Greiff… - Cancers, 2023 - mdpi.com
inflamed’ and ‘immune-excluded’). In conclusion, this study describes the spatial heterogeneity
… ’ and ‘surrounding stromal leukocyte’ regions vary.The study highlights immunological …

Inference on spatial heterogeneity in tumor microenvironment using spatial transcriptomics data

A Biswas, B Ghaddar, G Riedlinger… - … and systems oncology, 2022 - Wiley Online Library
… signatures contributed to most regional variations in pathway … distributed, the inflammation
signature had substantial loading … that inflammation signatures also contribute to regional

Mapping of inflammatory bowel disease in northern France: spatial variations and relation to affluence

C Declercq, C Gower-Rousseau… - Inflammatory bowel …, 2010 - academic.oup.com
… , mapping depicted spatial heterogeneity in the SIR with spatial autocorrelation. A high
relative risk (RR) of CD was observed in mainly rural and periurban cantons of the region. For UC…

Spatial heterogeneity can lead to substantial local variations in COVID-19 timing and severity

LJ Thomas, P Huang, F Yin, XI Luo… - Proceedings of the …, 2020 - National Acad Sciences
spatial heterogeneity at local scales (eg, within cities). Past work, however, has shown evidence
of substantial heterogeneity in social relationships at regional, … as regional identification (…

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

N Desai, A Neyaz, A Szabolcs, AR Shih… - Nature …, 2020 - nature.com
… expressed in regions of SARS-CoV-2 virus and not as a generalized inflammatory response
in lung. … never infected regions of lung or unresponsive lung regions with SARS-CoV-2 virus. …

[HTML][HTML] Beyond immune density: critical role of spatial heterogeneity in estrogen receptor-negative breast cancer

S Nawaz, A Heindl, K Koelble, Y Yuan - Modern Pathology, 2015 - Elsevier
… on whether infiltration by mononuclear inflammatory cells is present, thus … regions of high
cell density but regions of significantly high cell density, which indicates spatial heterogeneity