… -U [31] and we later proposed that they are a pathological marker for familial FTD caused
by a specific gene defect [20]. Although lentiform NII are an absolutely sensitive marker for …

… This study aimed to determine whether progranulin (PGRN), a major modulator of microglial
activity, plays a role in the progressive damage following TBI. PGRN-deficient and wild-type …

… Since the discovery of progranulin mutations there has been an interest in developing
mouse models of progranulin deficiency with the expectation that aspects of the pathological …

… ) due to progranulin (GRN) mutations, but their pathological … , then selected five different
brain regions directly matched to … We used immunohistochemistry to assess vascular pathology…

… pathologic substrate of corticobasal syndrome has been further expanded to include cases
with pathologic … 43)-positive inclusions associated with progranulin (PGRN) mutations. We …

… We do not find a deficit for working memory in this series. The detailed description of the
2 cases with a GRN mutation are said to have normal memory. We find a relative deficit for …

… We characterized the brain pathology related to NCL in aged PGRN-deficient mice in the
present study. PGRN deficiency resulted in neuronal loss, increased gliosis, lipofuscin …

… of progranulin message upstream of the Grn D region, … deficient immunoprotection in this
region. These changes might be related to the development of HS and/or TDP-43 pathology in …

… Heterozygous loss-of-function mutations in the progranulin (… Recently, it has been shown
that a complete GRN deficiency … a risk factor for FTLD-TDP pathology. In line with a potential …

… lead to progranulin … progranulin-deficient FTD and NCL remains unexplored. Now, Ward
et al. show that patients with heterozygous GRN mutations exhibit clinical and pathological …