Regulation of cellular senescence by p53
K Itahana, G Dimri, J Campisi - European journal of …, 2001 - Wiley Online Library
… of cellular senescence. This review will help place the regulation and role of p53 in cellular
senescence in the contexts of the evolution of complex multicellular organisms, and cellular …
senescence in the contexts of the evolution of complex multicellular organisms, and cellular …
Mechanisms and regulation of cellular senescence
L Roger, F Tomas, V Gire - International journal of molecular sciences, 2021 - mdpi.com
… Here, we describe some examples of this diversity of senescent cell types, focusing on …
cellular senescence to aging and cancer development. We also discuss the functions, regulation, …
cellular senescence to aging and cancer development. We also discuss the functions, regulation, …
Epigenetic regulation of cellular senescence
J Crouch, M Shvedova, RJRS Thanapaul… - Cells, 2022 - mdpi.com
… in senescent cells are crucial to the induction, progression, and maintenance of senescence…
This review will highlight some of the epigenetic mechanisms mediating cellular senescence…
This review will highlight some of the epigenetic mechanisms mediating cellular senescence…
Transcriptional regulation of cellular senescence
F Lanigan, JG Geraghty, AP Bracken - Oncogene, 2011 - nature.com
… established that cellular senescence is, like apoptosis, an inherent cellular defense that acts
… cellular senescence, focusing on recent findings with regard to the transcriptional regulation …
… cellular senescence, focusing on recent findings with regard to the transcriptional regulation …
Role of p53 in the regulation of cellular senescence
M Mijit, V Caracciolo, A Melillo, F Amicarelli… - Biomolecules, 2020 - mdpi.com
… dependent senescence signaling pathways involved with different stages of senescence and
… We also provide an overview on the regulation of p53-mediated cellular senescence in the …
… We also provide an overview on the regulation of p53-mediated cellular senescence in the …
The regulation of cellular functions by the p53 protein: cellular senescence
CA Tonnessen-Murray… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
… models, and clinical data has revealed that cellular senescence plays a vital role in p53-mediated
tumor suppression. Cellular senescence is a permanent cell-cycle arrest caused by …
tumor suppression. Cellular senescence is a permanent cell-cycle arrest caused by …
Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
RM Alani, AZ Young… - Proceedings of the …, 2001 - National Acad Sciences
… and because both are capable of inducing cellular senescence, we sought to determine
whether Id1 regulation of cellular senescence could be mediated by direct transcriptional effects …
whether Id1 regulation of cellular senescence could be mediated by direct transcriptional effects …
Epigenetic regulation of cellular senescence and aging
C Sidler, O Kovalchuk, I Kovalchuk - Frontiers in genetics, 2017 - frontiersin.org
… Below, we will summarize knowledge on the molecular mechanisms that underlie cellular
senescence and promote aging at the cellular level. We will also examine mechanisms that …
senescence and promote aging at the cellular level. We will also examine mechanisms that …
Non-cell-autonomous regulation of cellular senescence in cancer
D Di Mitri, A Alimonti - Trends in cell biology, 2016 - cell.com
… in the regulation of cellular senescence. Indeed, cytokines belonging to the senescent
secretome, as well as tumor-infiltrating immune subsets, have been described to modulate the …
secretome, as well as tumor-infiltrating immune subsets, have been described to modulate the …
Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
N Ohtani, E Hara - Cancer science, 2013 - Wiley Online Library
… the molecular and cellular biology of cellular senescence is … precise mechanisms of cellular
and organismal homeostatic … molecular mechanisms maintaining cellular homeostasis and …
and organismal homeostatic … molecular mechanisms maintaining cellular homeostasis and …
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