… regulatory functions for mitochondria in the mature oocyte, preimplantation stage embryo and
differentiating embryonic … determination of oocyte and embryo developmental competence, …

… occur throughout preimplantation embryo development, … , during human preimplantation
embryo development and defined … preimplantation embryo development in cell cycle regulation, …

… on cultured embryos. Consequently, studies on the epigenetic regulation of embryogenesis
… In this review, comparative information on epigenetic regulation of embryo development is …

… that were studied mostly in the mouse and review the literature on human embryos to see …
during human preimplantation development, we discuss how mechanical forces and their …

… its regulation, in two steps. First we will concentrate on the preimplantation embryo and the
regulation … lineage that differentiates from the preimplantation embryo, the trophoblast, which …

… We present an overview of the current understanding of embryonic metabolism in the
context of epigenetic regulation and explore how their interdependence could influence …

… Cell activities within the developing embryo are modulated through genetic regulatory
networks and concentration gradients of diffusible chemicals, known as morphogens [1], [2]. In …

… Separately, PFK1, a rate-limiting glycolytic enzyme, is released from allosteric regulation
and increases its activity >100-fold between pH 7.0 and 7.5 (Bock and Frieden 1976a, …

… preimplantation embryo will play a key role in integrating these two faces of the same coin. …
capturing its appearance and regulation could be key to model preimplantation development. …

… If true, this isolates a significant source of stochasticity and we should next investigate how
it is regulated, asking to what extent is the resultant inter-embryo variation still present before …