… Here we discuss the principal structure and function of ISs. We then focus on two … regulation
of LFA-1, we then explain how different APCs can induce functionally distinct T-cell effectors. …

… by which effectors are regulated within host cells are poorly understood. Metaeffectors
provide an additional layer of regulation and spatiotemporal fine-tuning of effector function. …

… of the gene expression specific to effector Treg cells, identifying Myb as a critical component
of the gene regulatory network controlling effector Treg cell differentiation and function. …

… , and detailed molecular mechanisms that regulate mTOR signaling in different T cell subsets…
and its regulation in the differentiation and function of regulatory T cells and effector T cells. …

… The expression or activity of counter-regulatory transcription factors functions in a graded
manner to regulate effector and memory T cell differentiation. Such transcription factor pairs …

… effector B (Beff) cells but also regulatory B (Breg) cells. There are two opposing B cell subsets;
Beff cells … This section focuses on the Beff cell subset and what is known about its function …

… Foxp3 + T-reg cells migrate to CNS during autoimmune … effector cells interfered with inhibitory
effects of the T-reg cells… + T-reg cells convert them into IL-17 producing T cells. This raises …

… on effector T cells and Tregs, to reinvigorate T cell effector function and block Treg-suppressive
function… mAbs that could promote effector CD4 + and CD8 + T cell proliferation, inhibit the …

… Although CD40 expression is not required for mouse B10 cell development [47], B-cell
regulatory functions are enhanced by ex vivo CD40 signaling in both inflammation and …

… To determine whether lower SATB1 expression was required for T reg cells to exert regulatory
function, we overexpressed SATB1 in human natural CD4 + CD25 hi Foxp3 + T reg cells …