… In addition, the differentiation factors responsible for their generation have revealed an
interesting reciprocal relationship with regulatory T (T reg ) cells, which prevent tissue …

… ), suggesting that RORγt may not be solely responsible for the Th17 cell effector program.
Our transcriptional regulatory network analysis of Th17 cells also identified RORα as a key …

… bind to other regulatory proteins via “effector” domains. In this chapter, we provide examples
of common effector domains that can function in transcriptional regulation via their ability to (…

… in follicular helper T cells, regulatory T cells, and other T cell subsets. Our … cell function in
autoimmune diseases such as lupus as well as in cancer immunotherapy through CAR-T cell …

… the adult reservoir of innate-like γδ T cell effectors. γδ T cell effectors can be defined by
various cell surface markers: IFNγ producing γδ T cells typically express CD27, CD122, NK1.1, …

… in follicular T helper cell development was … regulator of other specialized helper T-cell
subsets within germinal centers, pre-germinal center events, and peripheral T-cell effector functions…

… is to understand the regulatory mechanisms that underpin the … effector (Teffs) or regulatory
(Tregs) T-cell responses. Understanding the molecular mechanisms underlying the regulation …

… cell subset, outperformed late-differentiated effector memory–like T reg cells in regulatory
function… High yields of stable, functional T reg cell products could be achieved by depleting the …

… Here, we review our current understanding of gene-specific regulatory networks that define
… The transcriptional regulatory networks that control mammalian T cell effector functions are …

… a critical regulator of both the inductive and effector phases … function is limited to the
hemopoietic cellular compartment. Thus, the major microbicidal mechanisms as well as effector cells …