… In this study, we have identified uniquely regulated cytokines in virus-specific CD8 + T
cells that vary according to the differentiation state of the T-cell population and whether the …

… the first 3 days of a response to Ag and costimulation, IL-12 not only signals for development
of effector functions, but also programs the cells to survive as functional memory cells. …

… for effector function in T cells but that this pathway is not necessary for proliferation or survival.
When activated T cells are … Thus, aerobic glycolysis is a metabolically regulated signaling …

… that iNKT cells specifically expressed the BTB–zinc finger transcriptional regulator PLZF. In
… To test if PLZF-deficient iNKT cells had these critical effector functions, we immunized wild-…

… on T cells can lead to resolution of inflammation by up-regulating the suppression function of
regulatory T cells and … Moreover, T cell TLR4 engagement by LPS leads to up-regulation of …

… When these memory cells are appropriately coordinated and regulated, the diversity of T-cell
effector phenotypes allows immune protection against a multitude of pathogenic …

… is regulated: is this controlled by dendritic cells conditioned in response to distinct pathogens
or is there selection by a more stochastically regulated process by which primed T cells …

… of NK cell differentiation. Here, we review advances in our understanding of mature NK
cell development and plasticity with regards to regulation of cellular function. Furthermore, we …

… a regulatory function for the CD4+ T-cell compartment (29). Thus, ACD appears very different
from … DTH reactions in terms of T-cell subsets involved in effector proinflammatory functions. …

… T-cell resistance to suppression and enhanced Treg function are … effector response freedom
to generate protective immunity when it counts, but ‘tuned-up’ Treg function gives regulatory …