… in experimental models and regulatory pathways active in OA … regulatory pathway will be
insufficient in preventing or inhibiting OA development. Instead, multiple regulatory pathways …

… pathways and key molecules involved in OA pathogenesis is … roles and regulation of the
pathological signaling pathways, … and FGF signaling pathways, and key regulators AMPK, mTOR…

… elementary pathogenic aspects including genetic predisposition and epigenetic regulation
and … today generally accepted to drive inflammation and tissue destruction in osteoarthritis. …

… OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a
particular focus on DNA methylation, histone modification, and microRNA regulation, followed …

… regulatory transcriptional factor 1 (MTF1), have been reported to mediate OA pathogenesis
… Evidently, the HIF-2α and MTF1 transcriptional regulatory pathways induce MMPs including …

… A comprehensive review of the literature on osteoarthritis and … regulatory factors and
signaling pathways associated with chondrocyte apoptosis in osteoarthritis and other pathogenic …

… Osteoarthritis (OA) is one of the most common disabling pathologies, characterized by
joint … Hence, this review highlights the recent findings on the main pathways involved in OA …

… between joint inflammation and the pathogenesis of osteoarthritis. The mechanism by
which inflammation contributes to the pathogenesis of osteoarthritis will also be discussed. …

… This Review focuses on aberrant metabolism in the pathogenesis of OA, summarizing the
… research, such as the potential to target metabolic pathways and mediators therapeutically. …

… Later in this chapter, we will discuss the role played by these cytokines in OA pathogenesis
… , respectively), and Atg5 are four major regulators of the autophagy pathway [206]. ULK1 is a …