Regulatory T cells: how do they suppress immune responses?

…, Y Onishi, P Prieto-Martin, T Yamaguchi - International …, 2009 - academic.oup.com
Regulatory T cells (Tregs), either natural or induced, suppress a variety of physiological and
pathological immune responses. One of the key issues for understanding Treg function is to …

Regulatory T cells and mechanisms of immune system control

A O'garra, P Vieira - Nature medicine, 2004 - nature.com
… mechanisms used by T reg cells to suppress the immune system. … regulatory T cells arise
after H. hepaticus infection and require activation by a specific antigen to manifest their function. …

[PDF][PDF] The characterization and role of regulatory T cells in immune reactions

JR Wilczynski, M Radwan, J Kalinka - Front Biosci, 2008 - researchgate.net
… of T cell populations suppressing cytotoxic responses, there … on naturally occurring T CD25+
cells capable of regulating … that regulatory T cells of different phenotype and function could …

[PDF][PDF] The role of microRNAs in regulatory T cells and in the immune response

TY Ha - Immune network, 2011 - synapse.koreamed.org
Regulatory T (Treg) cells are a distinct lymphocyte lineage endowed with inhibitory properties
that affect the activation of the immune system. Treg cells (also called suppressor T cells) …

FOXP3+ regulatory T cells in the human immune system

S Sakaguchi, M Miyara, CM Costantino… - Nature Reviews …, 2010 - nature.com
Regulatory T (T Reg ) cells expressing the transcription factor forkhead box P3 (… the immune
system. They are indispensable for the maintenance of dominant self tolerance and immune

Regulating the immune system: the induction of regulatory T cells in the periphery

JH Buckner, SF Ziegler - Arthritis Res Ther, 2004 - Springer
T-cell responses. This latter mechanism involves a recently described T-cell subset, known
as regulatory T cells… The present review will discuss the various types of regulatory T cells, as …

Regulatory T cell migration during an immune response

Y Ding, J Xu, JS Bromberg - Trends in immunology, 2012 - cell.com
regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune
response in … Activated regulatory T cells are the major T cell type emigrating from the skin …

Regulatory T cells: friend or foe in immunity to infection?

KHG Mills - Nature Reviews Immunology, 2004 - nature.com
regulatory T cells control immune responses to bacteria, viruses, parasites and fungi. This
article explores the possibility that regulatory T cells … anti-pathogen immune responses, and …

Control of Immune Responses by Naturally Arising CD4+ Regulatory T Cells That Express Toll-like Receptors

S Sakaguchi - The Journal of experimental medicine, 2003 - rupress.org
… activity, high antigen specificity, and immunologic memory of adaptive immunity. There is now
… the normal immune system harbors naturally arising CD4 + regulatory T (T R ) cells, which …

The initial phase of an immune response functions to activate regulatory T cells

WE O'Gorman, H Dooms, SH Thorne… - The Journal of …, 2009 - journals.aai.org
… -stimulated T cells induces STAT5 phosphorylation in endogenous Tregs To define the cells
that respond to IL-2 during an immune response, we used single cell biochemical analysis …