CD4 + Foxp3 + regulatory T-cells (Tregs) are a unique subset of helper T-cells, which regulate
immune response and establish peripheral tolerance. Tregs not only maintain the tone …

… by 'tissue-resident' regulatory T (T Reg ) cells to maintain their survival programmes within
specialized microenvironments. Adipose or gut tissue T Reg cells express restricted T cell …

… are also stimulated to proliferate, but they retain their regulatory function. Interleukin-6 (IL-6) …
effector T cells refractory to suppression by regulatory T cells. Following activation, T cells …

… Over the last decade, we have learned that these costimulatory molecules play a key role
in the now classical CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) that provide critical …

… cell pool in different tissue sites remain poorly understood. In this review, we focus on the
cytokine-, cell type-, and tissue-specific factors governing Treg cell … CD4 + T cells, and how …

… Introduction to Regulatory T-Cells This article will review the scientific literature and provide
an overview of Regulatory T-cell (T REG ) characterization, function, role in the immune …

… Regulatory T cells help maintain intestinal homeostasis by preventing inappropriate innate …
T cells that express Foxp3 and Tr1-like cells that produce IL-10 comprise the major regulatory …

… CD4 + T cells differentiate into highly suppressive T cells, termed regulatory T cells (Treg cells),
… Despite the recognition that T cells could play a “suppressor” role in the control of effector …

… role of cytokines, T Cell Receptor (TCR) and co-stimulatory/co-inhibitory molecules signaling,
location and metabolism on the homeostasis and stability of Treg cells. The potential for …

… cells impinge upon the breadth of the memory compartment, and … T cells available for de
novo responses. Recent work has found that regulatory T cells (Treg), a subset of CD4+ T cells, …