Elevated cortisol evidence in Alzheimer's disease (AD) patients prompted the hypothesis
that stress and glucocorticoids are involved in the development and/or maintenance of AD …

In this study, we investigated mice of the TgCRND8 line, an APP transgenic mouse model of
Alzheimer's disease (AD), with respect to behavioral, endocrinological, and …

Growing evidence indicates that physical and psychosocial stressors, in part acting through
the hypothalamic-pituitary-adrenal (HPA) axis, may accelerate the process of Alzheimer's …

Alzheimer's disease (AD) is often accompanied by changes in mood as well as increases in
circulating cortisol levels, suggesting that regulation of the stress responsive hypothalamic …

Various environmental and genetic factors influence the onset and progression of
Alzheimer's disease (AD). Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis …

Aged, cognitively-impaired rats (and humans) show hypothalamic-pituitary-adrenal (HPA)
hyperactivity that correlates with hippocampal damage. The resultant increase in plasma …

Alzheimer's disease (AD) is a progressive, dementing, whole-body disorder that presents
with decline in cognitive, behavioral, and emotional functions, as well as endocrine …

Activation of the hypothalamic-pituitary-adrenal (HPA) axis occurs in response to the
organism's innate need for homeostasis. The glucocorticoids (GCs) that are released into …

Hypothalamo-pituitary-adrenal (HPA)-axis hyperactivity is well established in a large
proportion of both Alzheimer's disease (AD) patients and idiopathic depression patients …

Chronic stress is considered a widely accepted risk factor for the development of
neuropsychiatric and neurological disorders. Indeed, high cortisol levels, and, thus …