Skp2 regulates androgen receptor through ubiquitin‐mediated degradation independent of Akt/mTOR pathways in prostate cancer
BACKGROUND The intervention of advanced prostate cancer (PCa) in patients has been
commonly depending on androgen deprivation therapy. Despite of tremendous research …
commonly depending on androgen deprivation therapy. Despite of tremendous research …
[HTML][HTML] Regulation of androgen receptor by E3 ubiquitin ligases: for more or less
B Li, W Lu, Z Chen - Receptors & clinical investigation, 2014 - ncbi.nlm.nih.gov
Prostate cancer (PCa) primarily depends on the dysregulations of androgen receptor (AR)
signaling pathway for the initiation and growth as well as recurrence after chemotherapy [1] …
signaling pathway for the initiation and growth as well as recurrence after chemotherapy [1] …
[HTML][HTML] Pharmacological inhibition of the SKP2/p300 signaling axis restricts castration-resistant prostate cancer
SKP2, an F-box protein of the SCF type of the E3 ubiquitin ligase complex, plays an
important function in driving tumorigenesis through the destruction of numerous tumor …
important function in driving tumorigenesis through the destruction of numerous tumor …
Androgens repress expression of the f‐box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells
J Jiang, Y Pan, KM Regan, C Wu, X Zhang… - The …, 2012 - Wiley Online Library
BACKGROUND Androgens control homeostasis of the normal prostate and growth of
prostate cancer (PCa) through the androgen receptor (AR) by regulating gene networks …
prostate cancer (PCa) through the androgen receptor (AR) by regulating gene networks …
The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
PL Nguyen, DI Lin, J Lei, M Fiorentino, E Mueller… - … Oncology: Seminars and …, 2011 - Elsevier
BACKGROUND: In several human cancers, overexpression of Skp2 (S-phase kinase
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …
An AR-Skp2 pathway for proliferation of androgen-dependent prostate-cancer cells
H Wang, D Sun, P Ji, J Mohler… - Journal of cell …, 2008 - journals.biologists.com
Androgen–androgen-receptor (androgen-AR) signaling in normal prostate epithelium
promotes terminal luminal epithelial cell differentiation. In androgen-dependent prostate …
promotes terminal luminal epithelial cell differentiation. In androgen-dependent prostate …
Difference in protein expression profile and chemotherapy drugs response of different progression stages of LNCaP sublines and other human prostate cancer cells
HP Lin, CY Lin, PH Hsiao, HD Wang, S Sheng Jiang… - PLoS …, 2013 - journals.plos.org
Androgen ablation therapy is the primary treatment for metastatic prostate cancer. However,
80-90% of the patients who receive androgen ablation therapy ultimately develop recurrent …
80-90% of the patients who receive androgen ablation therapy ultimately develop recurrent …
Skp2: a novel potential therapeutic target for prostate cancer
Z Wang, D Gao, H Fukushima, H Inuzuka, P Liu… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Prostate cancer is the most frequently diagnosed tumor in men and the second most
common cause of cancer-related death for males in the United States. It has been shown …
common cause of cancer-related death for males in the United States. It has been shown …
[HTML][HTML] Skp2 is associated with paclitaxel resistance in prostate cancer cells
Y Yang, Y Lu, L Wang, A Mizokami… - Oncology …, 2016 - spandidos-publications.com
Prostate cancer is the most commonly diagnosed tumor in men in the United States. Patients
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …
[HTML][HTML] SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination
W Lu, S Liu, B Li, Y Xie, C Adhiambo, Q Yang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Aberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is
frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms …
frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms …