Objectives. To confirm, in a study of a large, independent cohort of families with prostate
cancer, the findings of three segregation analyses that have suggested the existence of an …

Previous studies have demonstrated familial clustering of prostate cancer. To define the
nature of this familial aggregation and to assess whether Mendelian inheritance can explain …

A family-history cancer survey was conducted on 5,486 men who underwent a radical
prostatectomy, for clinically localized prostate cancer, in the Department of Urology at the …

Purpose: We evaluated the importance of positive family history, age at diagnosis and
history of vasectomy in predicting the risk for prostate cancer in the brothers of prostate …

OBJECTIVE: To review current literature on the hereditary aspects of prostate cancer and to
evaluate the importance of family history in history taking and screening for prostate cancer …

This chapter describes the application of the genetic epidemiological approach to the study
of human prostate cancer. We review the evidence for the familial clustering of prostate …

A genetic component in prostate cancer has been recognized for decades. Through
numerous epidemiological and molecular biological studies much evidence has …

Background: It is estimated that there will be more than 244 000 new prostate cancer cases
diagnosed and that more than 40 000 men will die of this disease during 1995. Evidence …

BACKGROUND Although all men age> 50 years are at an increased risk for the
development of prostate carcinoma, 2 major factors increase this risk: family history and …

Hereditary prostate cancer, a newly described variant of prostate cancer, is distinguished by
early age at onset and autosomal dominant inheritance within families. 1 We review the …